Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person Rothfels, Karen, 2020-09-16

Class:IdInstanceEdit:9700663
_displayNameRothfels, Karen, 2020-09-16
_timestamp2020-09-16 05:26:06
author[Person:1226097] Rothfels, Karen
dateTime2020-09-16 05:25:53
(created)[Summation:9700644] Based on studies with the oncogenic fusion protein NPM-ALK, ...
[Pathway:9700645] ALK mutants bind TKIs [Homo sapiens]
[FailedReaction:9700646] ASP-3026- resistant ALK mutants don't bind ASP-3026 [Homo sapiens]
[Reaction:9700647] Active ALK phosphorylates SRC [Homo sapiens]
[Reaction:9700648] Active ALK binds SRC [Homo sapiens]
[Pathway:9700649] Drug resistance of ALK mutants [Homo sapiens]
[NegativeRegulation:9700650] Negative regulation by 'ALK dimer:ligand:type I ALK binding TKI [plasma membrane]'
[Summation:9700651] SRC is phosphorylated on tyrosine 419 and tyrosine 216 downs...
[Summation:9700654] The human NPM:ALK fusion interacts with SRC in a ALK-kinase ...
[Reaction:9700655] Active ALK phosphorylates Src [Homo sapiens]
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No pathways have been reviewed or authored by Rothfels, Karen, 2020-09-16 (9700663)