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Details on Person ASP-3026- resistant ALK mutants don't bind ASP-3026

Class:IdFailedReaction:9700646
_displayNameASP-3026- resistant ALK mutants don't bind ASP-3026
_doReleaseTRUE
_timestamp2021-05-04 17:33:47
authored[InstanceEdit:9724129] Rothfels, Karen, 2021-03-22
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:9700663] Rothfels, Karen, 2020-09-16
disease[Disease:1500689] cancer
edited[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
entityFunctionalStatus[EntityFunctionalStatus:9717334] loss_of_function of ASP3026-resistant ALK mutants [plasma membrane]
input[ChemicalDrug:9702330] ASP-3026 [cytosol]
[DefinedSet:9717270] ASP3026-resistant ALK mutants [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9717267] TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors
[LiteratureReference:9715259] Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib
modified[InstanceEdit:9717338] Rothfels, Karen, 2021-03-08
[InstanceEdit:9724130] Rothfels, Karen, 2021-03-22
[InstanceEdit:9729590] Rothfels, Karen, 2021-04-30
[InstanceEdit:9729893] Rothfels, Karen, 2021-05-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameASP-3026- resistant ALK mutants don't bind ASP-3026
normalReaction
releaseDate2021-06-09
reviewed[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9700665] R-HSA-9700646.2
summation[Summation:9717314] The following ALK mutants are resistant to inhibition by ASP...
(hasEvent)[Pathway:9717264] ASP-3026-resistant ALK mutants [Homo sapiens]
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