Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person NVP-TAE684-resistant ALK mutants [plasma membrane]

Class:Id	DefinedSet:9700568
_displayName	NVP-TAE684-resistant ALK mutants [plasma membrane]
_timestamp	2021-10-28 16:39:29
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9700562] Rothfels, Karen, 2020-09-16
disease	[Disease:1500689] cancer
hasMember	[Complex:9701839] ALK L1152R dimer [plasma membrane] [Homo sapiens] [Complex:9700533] ALK I1171N dimer [plasma membrane] [Homo sapiens] [Complex:9701840] ALK L1198P dimer [plasma membrane] [Homo sapiens] [Complex:9701827] ALK D1203N dimer [plasma membrane] [Homo sapiens] [Complex:9700557] ALK A1234T dimer [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:9700412] Activating mutations in ALK provide a therapeutic target in neuroblastoma [LiteratureReference:9701779] A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors [LiteratureReference:9701773] ALK mutations conferring differential resistance to structurally diverse ALK inhibitors [LiteratureReference:9700339] Crizotinib-resistant NPM-ALK mutants confer differential sensitivity to unrelated Alk inhibitors [LiteratureReference:9717267] TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors
modified	[InstanceEdit:9701908] Rothfels, Karen, 2020-09-28 [InstanceEdit:9715308] Rothfels, Karen, 2021-02-17 [InstanceEdit:9717342] Rothfels, Karen, 2021-03-08 [InstanceEdit:9757297] Rothfels, Karen, 2021-10-28
name	NVP-TAE684-resistant ALK mutants
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9700574] R-HSA-9700568.2
(diseaseEntity)	[EntityFunctionalStatus:9717337] loss_of_function of NVP-TAE684-resistant ALK mutants [plasma membrane]
(input)	[FailedReaction:9700114] NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684 [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by NVP-TAE684-resistant ALK mutants [plasma membrane] (9700568)