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Details on Person brigatinib-sensitive ALK mutants [plasma membrane]

Class:Id	DefinedSet:9700552
_displayName	brigatinib-sensitive ALK mutants [plasma membrane]
_timestamp	2021-02-22 23:20:39
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9700562] Rothfels, Karen, 2020-09-16
disease	[Disease:1500689] cancer
hasMember	[Complex:9700005] ALK F1174V dimer [plasma membrane] [Homo sapiens] [Complex:9715315] ALK V1180L dimer [plasma membrane] [Homo sapiens] [Complex:9700521] ALK L1196Q dimer [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:9700357] Treatment Efficacy and Resistance Mechanisms Using the Second-Generation ALK Inhibitor AP26113 in Human NPM-ALK-Positive Anaplastic Large Cell Lymphoma [LiteratureReference:9700339] Crizotinib-resistant NPM-ALK mutants confer differential sensitivity to unrelated Alk inhibitors [LiteratureReference:9715259] Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib
modified	[InstanceEdit:9714074] Rothfels, Karen, 2021-02-02 [InstanceEdit:9715308] Rothfels, Karen, 2021-02-17 [InstanceEdit:9716606] Rothfels, Karen, 2021-02-22
name	brigatinib-sensitive ALK mutants
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9700585] R-HSA-9700552.1
(hasMember)	[DefinedSet:9699981] type I TKI sensitive ALK mutants [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by brigatinib-sensitive ALK mutants [plasma membrane] (9700552)