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Details on Person ceritinib-sensitive ALK mutants [plasma membrane]

Class:Id	DefinedSet:9700528
_displayName	ceritinib-sensitive ALK mutants [plasma membrane]
_timestamp	2021-02-22 23:20:41
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9700530] Rothfels, Karen, 2020-09-16
disease	[Disease:1500689] cancer
hasMember	[Complex:9700519] ALK I1171T dimer [plasma membrane] [Homo sapiens] [Complex:9699978] ALK F1174I dimer [plasma membrane] [Homo sapiens] [Complex:9700005] ALK F1174V dimer [plasma membrane] [Homo sapiens] [Complex:9715315] ALK V1180L dimer [plasma membrane] [Homo sapiens] [Complex:9701482] ALK S1206Y dimer [plasma membrane] [Homo sapiens] [Complex:9701828] ALK G1269A dimer [plasma membrane] [Homo sapiens] [Complex:9700022] EML4(1-486)-ALK(1058-1620) fusion dimer [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:9700350] The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer [LiteratureReference:9700357] Treatment Efficacy and Resistance Mechanisms Using the Second-Generation ALK Inhibitor AP26113 in Human NPM-ALK-Positive Anaplastic Large Cell Lymphoma
modified	[InstanceEdit:9700562] Rothfels, Karen, 2020-09-16 [InstanceEdit:9715308] Rothfels, Karen, 2021-02-17 [InstanceEdit:9716606] Rothfels, Karen, 2021-02-22
name	ceritinib-sensitive ALK mutants
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9700549] R-HSA-9700528.1
(hasMember)	[DefinedSet:9699981] type I TKI sensitive ALK mutants [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by ceritinib-sensitive ALK mutants [plasma membrane] (9700528)