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Details on Person Crizotinib-resistant NPM-ALK mutants confer differential sensitivity to unrelated Alk inhibitors

Class:Id	LiteratureReference:9700339
_displayName	Crizotinib-resistant NPM-ALK mutants confer differential sensitivity to unrelated Alk inhibitors
_timestamp	2020-09-16 05:14:47
author	[Person:9700313] Ceccon, Monica [Person:9699790] Mologni, Luca [Person:9700352] Bisson, William [Person:500816] Scapozza, L [Person:9647075] Gambacorti-Passerini, Carlo
created	[InstanceEdit:9700359] Rothfels, Karen, 2020-09-16
journal	Mol. Cancer Res.
pages	122-32
pubMedIdentifier	23239810
title	Crizotinib-resistant NPM-ALK mutants confer differential sensitivity to unrelated Alk inhibitors
volume	11
year	2013
(literatureReference)	[FailedReaction:9700114] NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684 [Homo sapiens] [Reaction:9700131] ALK mutants bind type I TKIs [Homo sapiens] [Reaction:9700184] Ligand-independent dimerization of point mutants of ALK [Homo sapiens] [Reaction:9700186] Autophosphorylation of point mutants of ALK [Homo sapiens] [Reaction:9700662] Liganded-ALK dimer binds type I ALK-binding TKIs [Homo sapiens] [FailedReaction:9715356] brigatinib-resistant ALK mutants don't bind brigatinib [Homo sapiens] [FailedReaction:9715357] crizotinib-resistant ALK mutants don't bind crizotinib [Homo sapiens] [Pathway:9717301] NVP-TAE684-resistant ALK mutants [Homo sapiens] [EntityWithAccessionedSequence:9699828] ALK I1171N [plasma membrane] [Homo sapiens] [DefinedSet:9700081] NVP-TAE684-sensitive ALK mutants [cytosol] [Homo sapiens] List all 15 refering instances
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No pathways have been reviewed or authored by Crizotinib-resistant NPM-ALK mutants confer differential sensitivity to unrelated Alk inhibitors (9700339)