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Query author contributions in Reactome

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Details on Person Diagram of Signaling by ALK, Signaling by ALK fusions and activated point mutants, ALK mutants bind TKIs, ASP-3026- resistant ALK mutants, NVP-TAE684-resistant ALK mutants, alectinib resistant ALK mutants, brigatinib-resistant ALK mutants, ceritinib-resistant ALK mutants, crizotinib-resistant ALK mutants, and lorlatinib-resistant ALK mutants

Class:IdPathwayDiagram:9700218
_displayNameDiagram of Signaling by ALK, Signaling by ALK fusions and activated point mutants, ALK mutants bind TKIs, ASP-3026- resistant ALK mutants, NVP-TAE684-resistant ALK mutants, alectinib resistant ALK mutants, brigatinib-resistant ALK mutants, ceritinib-resistant ALK mutants, crizotinib-resistant ALK mutants, and lorlatinib-resistant ALK mutants
_timestamp2024-03-06 04:44:45
created[InstanceEdit:9700219] Rothfels, Karen, 2020-09-14
height3631
modified[InstanceEdit:9700676] Rothfels, Karen, 2020-09-16
[InstanceEdit:9701571] Rothfels, Karen, 2020-09-26
[InstanceEdit:9701908] Rothfels, Karen, 2020-09-28
[InstanceEdit:9701950] Rothfels, Karen, 2020-09-28
[InstanceEdit:9702116] Rothfels, Karen, 2020-09-29
[InstanceEdit:9702335] Rothfels, Karen, 2020-09-29
[InstanceEdit:9710922] Rothfels, Karen, 2021-01-05
[InstanceEdit:9712099] Rothfels, Karen, 2021-01-14
[InstanceEdit:9713548] Rothfels, Karen, 2021-01-26
[InstanceEdit:9715353] Rothfels, Karen, 2021-02-17
[InstanceEdit:9718483] Rothfels, Karen, 2021-03-17
[InstanceEdit:9723900] Rothfels, Karen, 2021-03-18
[InstanceEdit:9724113] Rothfels, Karen, 2021-03-22
[InstanceEdit:9724129] Rothfels, Karen, 2021-03-22
[InstanceEdit:9724184] Rothfels, Karen, 2021-03-22
[InstanceEdit:9725039] Rothfels, Karen, 2021-03-26
[InstanceEdit:9725359] Rothfels, Karen, 2021-03-29
[InstanceEdit:9725372] Rothfels, Karen, 2021-03-29
[InstanceEdit:9725535] Rothfels, Karen, 2021-03-29
[InstanceEdit:9725662] Rothfels, Karen, 2021-03-30
[InstanceEdit:9730638] Matthews, Lisa, 2021-05-10
[InstanceEdit:9730715] Rothfels, Karen, 2021-05-10
[InstanceEdit:9730717] Rothfels, Karen, 2021-05-10
[InstanceEdit:9730732] Rothfels, Karen, 2021-05-10
[InstanceEdit:9730733] Rothfels, Karen, 2021-05-10
[InstanceEdit:9730925] Matthews, Lisa, 2021-05-12
[InstanceEdit:9730957] Rothfels, Karen, 2021-05-12
[InstanceEdit:9751184] Rothfels, Karen, 2021-08-19
[InstanceEdit:9751243] Matthews, Lisa, 2021-08-23
[InstanceEdit:9851173] Rothfels, Karen, 2023-10-13
[InstanceEdit:9851737] Rothfels, Karen, 2023-10-30
[InstanceEdit:9852715] Rothfels, Karen, 2023-11-06
[InstanceEdit:9853038] Rothfels, Karen, 2023-11-09
[InstanceEdit:9863731] Matthews, Lisa, 2024-03-05
[InstanceEdit:9863937] Matthews, Lisa, 2024-03-06
representedPathway[Pathway:201556] Signaling by ALK [Homo sapiens]
[Pathway:9725370] Signaling by ALK fusions and activated point mutants [Homo sapiens]
[Pathway:9700645] ALK mutants bind TKIs [Homo sapiens]
[Pathway:9717264] ASP-3026-resistant ALK mutants [Homo sapiens]
[Pathway:9717301] NVP-TAE684-resistant ALK mutants [Homo sapiens]
[Pathway:9717316] alectinib-resistant ALK mutants [Homo sapiens]
[Pathway:9717319] brigatinib-resistant ALK mutants [Homo sapiens]
[Pathway:9717323] ceritinib-resistant ALK mutants [Homo sapiens]
[Pathway:9717326] crizotinib-resistant ALK mutants [Homo sapiens]
[Pathway:9717329] lorlatinib-resistant ALK mutants [Homo sapiens]
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position="486 1635" bounds="462 1624 48 23" textPosition="462 1624"> <Properties> <displayName>PTPN6</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="13896" reactomeId="29372" position="471 1571" bounds="458 1556 27 31" textPosition="462 1560"> <Properties> <displayName>Pi</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="13898" reactomeId="539044" position="943 1180" bounds="920 1169 47 23" textPosition="920 1169"> <Properties> <displayName>STAT3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableCompartment id="13903" reactomeId="7660" position="1967 2231" bounds="1198 1219 1539 2025" textPosition="1793 1249" bgColor="250 240 240" lineColor="255 153 102" insets="1226 1246 1486 1976"> <Properties> <displayName>nucleoplasm</displayName> </Properties> <Components> <Component id="13980" /> <Component id="14015" /> <Component id="14016" /> <Component 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1442 85 52" textPosition="1978 1469"> <Properties> <displayName>PRDM1 Gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="14018" reactomeId="9701467" position="2279 1529" bounds="2212 1504 135 51" textPosition="2212 1505" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SIN3A:AcK685,p-Y705,p-S727 STAT3 dimer:PRDM1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="14020" reactomeId="6804199" position="2367 1465" bounds="2342 1454 51 23" textPosition="2342 1454"> <Properties> <displayName>PRDM1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="14034" reactomeId="113560" position="1778 1683" bounds="1748 1668 61 31" textPosition="1752 1672"> <Properties> <displayName>Ac-CoA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="14035" reactomeId="2485002" position="1931 1699" bounds="1900 1684 62 31" textPosition="1904 1688"> <Properties> <displayName>CoA-SH</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="14036" reactomeId="381325" position="1845 1618" bounds="1822 1607 47 23" textPosition="1822 1607"> <Properties> <displayName>EP300</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="14054" reactomeId="427486" position="1761 1531" bounds="1724 1516 75 31" textPosition="1728 1520"> <Properties> <displayName>CH3COO-</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableGene id="14069" reactomeId="9701417" position="2168 1639" bounds="2131 1613 75 52" textPosition="2131 1640"> <Properties> <displayName>IL2RG gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="14070" reactomeId="9701471" position="2555 1576" bounds="2495 1551 120 51" textPosition="2495 1552" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SIN3A:ACK685-p-Y705,S727 STAT3 dimer:IL2RG gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="14078" reactomeId="449139" position="3005 1635" bounds="2984 1624 43 23" textPosition="2984 1624"> <Properties> <displayName>IL2RG</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="14083" reactomeId="8948427" position="1576 1470" bounds="1539 1444 75 52" textPosition="1539 1471"> <Properties> <displayName>HIF1A gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="14084" reactomeId="9701459" position="1539 1313" bounds="1476 1288 127 51" textPosition="1476 1289" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-Y705, S727 STAT3 dimer:HIF1A gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="14086" reactomeId="1234135" position="1704 1459" bounds="1683 1448 43 23" textPosition="1683 1448"> <Properties> <displayName>HIF1A</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="14087" reactomeId="205005" position="1856 1488" bounds="1794 1477 124 23" textPosition="1794 1477"> <Properties> <displayName>Histone deacetylase</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="14090" reactomeId="113518" position="1937 1523" bounds="1916 1508 43 31" textPosition="1920 1512"> <Properties> <displayName>H2O</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableGene id="14098" reactomeId="9701419" position="1967 1394" bounds="1926 1368 82 52" textPosition="1926 1395"> <Properties> <displayName>CD274 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="14099" reactomeId="9701462" position="2246 1319" bounds="2179 1294 134 51" textPosition="2177 1309" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-Y705, S727 STAT3 dimer:CD274 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="14101" reactomeId="3211776" position="3004 1388" bounds="2979 1377 50 23" textPosition="2979 1377"> <Properties> <displayName>CD274</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="14230" reactomeId="9710874" position="1750 1023" bounds="1684 991 132 65" textPosition="1684 998" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>GRB2- and PLC gamma-binding ALK fusion protein dimers</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="14232" reactomeId="8983328" position="1720 1092" bounds="1700 1081 41 23" textPosition="1700 1081"> <Properties> <displayName>GRB2</displayName> </Properties> </org.gk.render.RenderableProtein> 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</org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="14466" reactomeId="179856" position="277 535" bounds="242 520 70 31" textPosition="246 524"> <Properties> <displayName>PI(4,5)P2</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="14467" reactomeId="113592" position="399 548" bounds="379 533 40 31" textPosition="383 537" /> <org.gk.render.RenderableProtein id="14562" reactomeId="74787" position="569 577" bounds="544 566 51 23" textPosition="544 566"> <Properties> <displayName>PIK3CA</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="14564" reactomeId="9711926" position="416 623" bounds="359 605 115 37" textPosition="359 606" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>PI3K-binding ALK fusions:PI3K</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="14566" reactomeId="74789" position="967 579" bounds="942 568 51 23" textPosition="942 568"> <Properties> <displayName>PIK3R1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="14567" reactomeId="9711929" position="937 656" bounds="880 638 115 37" textPosition="880 638" lineColor="255 0 0" lineWidth="1.0" isForDisease="true"> <Properties> <displayName>PI3K-binding ALK mutants</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="14570" reactomeId="9711928" position="781 606" bounds="718 595 127 23" textPosition="718 596" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>ALK mutants:PIK3R1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="14602" reactomeId="191476" position="1593 606" bounds="1569 595 49 23" textPosition="1569 595" lineWidth="1.0"> <Properties> <displayName>FRS2,3</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="14607" reactomeId="9711938" position="1782 654" bounds="1733 643 99 23" textPosition="1733 644" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>ALK fusions:FRS</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="14611" reactomeId="9712069" position="2033 655" bounds="1977 637 113 37" textPosition="1977 638" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>ALK fusions:p-6Y FRS</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="14709" reactomeId="9711940" position="1695 569" bounds="1648 551 94 37" textPosition="1648 552" bgColor="204 255 255" lineColor="255 0 0" lineWidth="1.0" isForDisease="true" hideComponents="true"> <Properties> <displayName>IRS:ALK fusion proteins</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="14711" reactomeId="113592" position="1782 606" bounds="1762 591 40 31" textPosition="1766 595" /> <org.gk.render.RenderableChemical id="14712" reactomeId="29370" position="1893 595" bounds="1873 580 41 31" textPosition="1877 584" /> <org.gk.render.RenderableComplex id="14713" reactomeId="9712076" position="1992 564" bounds="1928 546 128 37" textPosition="1928 547" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>p-Y IRS1:ALK fusion proteins</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="14774" reactomeId="9711944" position="831 1618" bounds="775 1600 112 37" textPosition="775 1600" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>STAT3-activating ALK mutants</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="14779" reactomeId="9711935" position="919 1746" bounds="858 1728 123 37" textPosition="858 1729" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>STAT3-activating ALK mutants:STAT3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="14781" reactomeId="113592" position="1020 1779" bounds="1000 1764 40 31" textPosition="1004 1768" /> <org.gk.render.RenderableComplex id="14782" reactomeId="9712038" position="933 1908" bounds="877 1883 112 51" textPosition="877 1884" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>STAT3-activating ALK mutants:p-Y STAT3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="14783" reactomeId="29370" position="861 1852" bounds="841 1837 41 31" textPosition="845 1841" /> <org.gk.render.RenderableEntitySet id="14784" reactomeId="9713538" position="1681 773" bounds="1625 755 112 37" textPosition="1625 755" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>SHC-binding ALK mutant dimers</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableGene id="14837" reactomeId="9701805" position="1286 1969" bounds="1243 1943 87 52" textPosition="1243 1970"> <Properties> <displayName>STAT5A gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableEntitySet id="14838" reactomeId="9005549" position="1289 1886" bounds="1265 1875 49 23" textPosition="1265 1875"> <Properties> <displayName>MECP2</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="14839" reactomeId="9701804" position="1492 1869" bounds="1437 1850 111 39" textPosition="1441 1853" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:STAT5A gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="14847" reactomeId="9701901" position="1519 1948" bounds="1492 1937 55 23" textPosition="1492 1937"> <Properties> <displayName>STAT5A</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="14873" reactomeId="9718460" position="1425 1081" bounds="1361 1063 129 37" textPosition="1361 1063" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>MYH9- and RNF213-ALK fusions</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="14874" reactomeId="9724089" position="1606 1089" bounds="1542 1071 129 37" textPosition="1542 1071" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>p-7Y MYH9- and RNF213-ALK fusions</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="14926" reactomeId="9724097" position="2113 1094" bounds="2055 1076 117 37" textPosition="2055 1077" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>ALK fusion dimers:p-3Y SHC1:GRB2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="15259" reactomeId="9725002" position="1429 2558" bounds="1374 2540 111 37" textPosition="1374 2541" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CUL1:RBX1:SKP1:ZC3HC1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="15260" reactomeId="9725012" position="1373 2672" bounds="1308 2647 131 51" textPosition="1308 2648" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true" /> <org.gk.render.RenderableComplex id="15261" reactomeId="9725021" position="1553 2598" bounds="1491 2573 125 51" textPosition="1491 2574" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>NPM1-p-7Y ALK fusion dimer:CUL1:RBX1:SKP1:ZC3HC1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="15263" reactomeId="29358" position="1630 2551" bounds="1610 2536 40 31" textPosition="1614 2540"> <Properties> <displayName>ATP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="15264" reactomeId="9725027" position="1790 2598" bounds="1727 2566 126 65" textPosition="1727 2567" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>NPM1p-7Y ALK fusion dimer:CUL1:RBX1:SKP1:p-S354 ZC3HC1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="15265" reactomeId="113582" position="1723 2537" bounds="1703 2522 41 31" textPosition="1707 2526" /> <org.gk.render.RenderableComplex id="15266" reactomeId="109856" position="1680 2490" bounds="1633 2472 94 37" textPosition="1633 2473" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-Y185,Y187 MAPK1 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="15275" reactomeId="9699991" position="1097 2675" bounds="1032 2650 131 51" textPosition="1032 2651" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="15276" reactomeId="9724998" position="1130 2560" bounds="1094 2549 73 23" textPosition="1094 2550" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NPM dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="15284" reactomeId="9725096" position="1270 1561" bounds="1239 1535 63 52" textPosition="1239 1562"> <Properties> <displayName>ALK gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="15285" reactomeId="9725109" position="1321 1449" bounds="1269 1431 104 37" textPosition="1269 1432" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MYC/MYCN:ALK gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="15326" reactomeId="3215043" position="1416 1541" bounds="1380 1530 72 23" textPosition="1380 1530"> <Properties> <displayName>MYC,MYCN</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableGene id="15409" reactomeId="2187294" position="1792 2769" bounds="1758 2743 69 52" textPosition="1758 2770"> <Properties> <displayName>JUNB gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="15410" reactomeId="2186795" position="2503 2838" bounds="2485 2827 37 23" textPosition="2485 2827"> <Properties> <displayName>JUNB</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="15413" reactomeId="5674341" position="2059 2704" bounds="2009 2679 100 51" textPosition="2009 2679"> <Properties> <displayName>p-T,Y MAPK monomers and dimers</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableRNA id="15434" reactomeId="9725326" position="2828 2734" bounds="2774 2715 109 39" textPosition="2790 2723"> <Properties> <displayName>JUNB mRNA</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableProtein id="15436" reactomeId="165727" position="2859 2828" bounds="2821 2814 76 29" textPosition="2822 2817"> <Properties> <displayName>p-5S-RPS6</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.21052631578947367" relativeY="0.0" label="P" trackId="0" reactomeId="165729" /> <org.gk.render.RenderableFeature relativeX="0.42105263157894735" relativeY="0.0" label="P" trackId="0" reactomeId="165735" /> <org.gk.render.RenderableFeature relativeX="0.631578947368421" relativeY="0.0" label="P" trackId="0" reactomeId="165734" /> <org.gk.render.RenderableFeature relativeX="1.0" relativeY="0.5517241379310345" label="P" trackId="0" reactomeId="165732" /> <org.gk.render.RenderableFeature relativeX="0.7894736842105263" relativeY="1.0" label="P" trackId="0" reactomeId="165731" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="15461" reactomeId="9725309" position="1471 3187" bounds="1428 3161 86 52" textPosition="1428 3188"> <Properties> <displayName>BCL2A1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="15462" reactomeId="9725307" position="1600 3287" bounds="1568 3276 64 23" textPosition="1573 3276"> <Properties> <displayName>BCL2A1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="15473" reactomeId="3858376" position="1923 2599" bounds="1885 2573 77 52" textPosition="1885 2600"> <Properties> <displayName>CEBPB gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="15474" reactomeId="381378" position="2192 2575" bounds="2170 2564 45 23" textPosition="2170 2564"> <Properties> <displayName>CEBPB</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="15475" reactomeId="9713536" position="1468 664" bounds="1408 639 120 51" textPosition="1408 639" lineColor="255 0 0" lineWidth="1.0" isForDisease="true"> <Properties> <displayName>IRS- and FRS-binding ALK fusion proteins</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="15511" reactomeId="9842597" position="230 158" bounds="176 147 109 23" textPosition="176 147"> <Properties> <displayName>ALKAL2:(ALKAL1)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="15512" reactomeId="9842608" position="507 307" bounds="447 289 121 37" textPosition="447 290" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ALK dimer:ALKAL2:(ALKAL1)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="15519" reactomeId="113592" position="813 398" bounds="793 383 40 31" textPosition="797 387" /> <org.gk.render.RenderableEntitySet id="15520" reactomeId="9850908" position="742 349" bounds="683 331 118 37" textPosition="683 331"> <Properties> <displayName>ligand-bound ALK dimer</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="15541" reactomeId="9850879" position="1242 339" bounds="1189 328 107 23" textPosition="1189 328"> <Properties> <displayName>Active ALK dimer</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="15544" reactomeId="29370" position="978 390" bounds="958 375 41 31" textPosition="962 379" /> <org.gk.render.RenderableGene id="15550" reactomeId="9725313" position="1274 1368" bounds="1237 1342 75 52" textPosition="1237 1369"> <Properties> <displayName>MYCN gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="15551" reactomeId="452357" position="1382 1345" bounds="1361 1334 43 23" textPosition="1361 1334"> <Properties> <displayName>MYCN</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="15587" reactomeId="201502" position="213 2054" bounds="198 2043 31 23" textPosition="198 2043" /> <org.gk.render.RenderableEntitySet id="15622" reactomeId="9699986" position="143 2137" bounds="111 2126 64 23" textPosition="111 2126"> <Properties> <displayName>PTN,MDK</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableGene id="15631" reactomeId="9845024" position="2214 2418" bounds="2181 2392 67 52" textPosition="2181 2419"> <Properties> <displayName>ICOS gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="15632" reactomeId="9850889" position="2250 2286" bounds="2188 2275 124 23" textPosition="2188 2276" bgColor="204 255 255" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>ICOS gene:p-STAT3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="15654" reactomeId="9850886" position="3008 2407" bounds="2972 2396 73 23" textPosition="2972 2397" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ICOS dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="15672" reactomeId="8948451" position="1644 2401" bounds="1602 2375 84 52" textPosition="1602 2402"> <Properties> <displayName>TWIST1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="15673" reactomeId="445442" position="1824 2378" bounds="1798 2367 52 23" textPosition="1798 2367"> <Properties> <displayName>TWIST1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="15724" reactomeId="8948472" position="2139 2208" bounds="2106 2182 66 52" textPosition="2106 2209"> <Properties> <displayName>IRF4 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="15726" reactomeId="9850945" position="2391 2141" bounds="2324 2123 135 37" textPosition="2324 2124" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>pY705, S727-STAT3 dimer:IRF4 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="15728" reactomeId="1015679" position="2825 2225" bounds="2808 2214 34 23" textPosition="2808 2214"> <Properties> <displayName>IRF4</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="15738" reactomeId="606320" position="1301 2755" bounds="1280 2744 43 23" textPosition="1280 2744"> <Properties> <displayName>NPM1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="15740" reactomeId="4088019" position="1297 2714" bounds="1272 2703 50 23" textPosition="1272 2703"> <Properties> <displayName>FOXM1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="15741" reactomeId="9850901" position="1375 2801" bounds="1318 2783 114 37" textPosition="1318 2784" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>NPM1-ALK;NPM1:FOXM1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="15747" reactomeId="4088295" position="1288 2887" bounds="1247 2861 83 52" textPosition="1247 2888"> <Properties> <displayName>CCNB1 Gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="15748" reactomeId="68901" position="1456 2862" bounds="1432 2851 49 23" textPosition="1432 2851"> <Properties> <displayName>CCNB1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="15783" reactomeId="9850859" position="1698 3170" bounds="1657 3144 82 52" textPosition="1657 3171"> <Properties> <displayName>IL10RA gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="15784" reactomeId="449841" position="1765 3511" bounds="1740 3500 50 23" textPosition="1740 3500"> <Properties> <displayName>IL10RA</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="15785" reactomeId="9850905" position="1874 3351" bounds="1808 3333 133 37" textPosition="1808 3334" bgColor="184 154 230" fgColor="161 1 2" lineColor="255 0 0" isForDrug="true" isForDisease="true" hideComponents="true"> <Properties> <displayName>crizotinib:NPM1-ALK fusion dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="15790" reactomeId="6783783" position="1556 3519" bounds="1494 3493 125 53" textPosition="1505 3497"> <Properties> <displayName>Interleukin-10 signaling</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableGene id="15818" reactomeId="1911481" position="1527 2313" bounds="1481 2287 92 52" textPosition="1481 2314"> <Properties> <displayName>NOTCH1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="15819" reactomeId="9850937" position="1334 2240" bounds="1284 2215 100 51" textPosition="1284 2216" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-Y705,S727 -STAT3 dimer: NOTCH gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableRNA id="15821" reactomeId="1606559" position="960 2308" bounds="894 2289 132 39" textPosition="910 2297"> <Properties> <displayName>NOTCH1 mRNA</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableComplex id="15838" reactomeId="9850883" position="2563 1720" bounds="2501 1695 125 51" textPosition="2501 1696" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="15844" reactomeId="212181" position="2238 1785" bounds="2212 1774 53 23" textPosition="2212 1774"> <Properties> <displayName>DNMT1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="15884" reactomeId="9850864" position="2169 2086" bounds="2130 2060 78 52" textPosition="2130 2087"> <Properties> <displayName>MIR21 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="15885" reactomeId="9850896" position="2571 1977" bounds="2511 1952 120 51" textPosition="2511 1953" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MIR21 gene:AcK685-pY705,p-S727 STAT3 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="15891" reactomeId="9850916" position="2866 2037" bounds="2828 2026 76 23" textPosition="2828 2026"> <Properties> <displayName>miR21 RISC</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableRNA id="15910" reactomeId="9850861" position="2835 1840" bounds="2773 1821 125 39" textPosition="2789 1829"> <Properties> <displayName>DNMT1 mRNA</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableComplex id="15911" reactomeId="9850915" position="2864 1702" bounds="2797 1684 135 37" textPosition="2797 1685" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>miR-21 RISC:DNMT1 mRNA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="15926" reactomeId="5660405" position="2270 1834" bounds="2228 1808 85 52" textPosition="2228 1835"> <Properties> <displayName>DNMT1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="15927" reactomeId="9850875" position="2554 1913" bounds="2491 1888 126 51" textPosition="2491 1889" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>AcK685-p-Y705, S727-STAT3 dimer:DNMT1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="15991" reactomeId="205021" position="1447 2003" bounds="1422 1992 51 23" textPosition="1422 1992"> <Properties> <displayName>HDAC1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="15992" reactomeId="9850942" position="1330 2045" bounds="1267 2020 126 51" textPosition="1267 2021" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>pY705, S727 STAT dimer:DNMT1:HDAC1:PTPN6 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="16005" reactomeId="1257604" position="2863 2981" bounds="2794 2951 138 60" textPosition="2799 2959" /> <org.gk.render.RenderableGene id="16062" reactomeId="9850852" position="1849 1843" bounds="1810 1817 79 52" textPosition="1810 1844"> <Properties> <displayName>ZAP70 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="16063" reactomeId="202397" position="1973 1765" bounds="1950 1754 47 23" textPosition="1950 1754"> <Properties> <displayName>ZAP70</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="16121" reactomeId="2976052" position="2365 2931" bounds="2327 2905 76 52" textPosition="2327 2932"> <Properties> <displayName>GZMB Gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="16122" reactomeId="9850873" position="2198 2839" bounds="2143 2821 110 37" textPosition="2143 2822" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>GZMB gene:JUNB dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="16124" reactomeId="6807037" position="2206 3324" bounds="2185 3313 42 23" textPosition="2185 3313"> <Properties> <displayName>GZMB</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableCompartment id="16125" reactomeId="8857380" position="2194 3340" bounds="2082 3289 225 103" textPosition="2119 3340" bgColor="250 240 240" lineColor="255 153 102" insets="2094 3304 197 79"> <Properties> <displayName>cytolytic granule lumen</displayName> </Properties> <Components> <Component id="16124" /> <Component id="16128" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableGene id="16127" reactomeId="9850855" position="1925 2941" bounds="1890 2915 70 52" textPosition="1890 2942"> <Properties> <displayName>PRF1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="16128" reactomeId="9850839" position="2155 3329" bounds="2136 3318 38 23" textPosition="2136 3318"> <Properties> <displayName>PRF1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="16182" reactomeId="8948437" position="1328 3179" bounds="1292 3153 73 52" textPosition="1292 3180"> <Properties> <displayName>MCL1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="16183" reactomeId="5661490" position="1143 3152" bounds="1123 3141 41 23" textPosition="1123 3141"> <Properties> <displayName>MCL1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="16184" reactomeId="909682" position="1156 3364" bounds="1100 3346 113 37" textPosition="1100 3346"> <Properties> <displayName>p-Y1054,Y1055-TYK2</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.1415929203539823" relativeY="0.0" label="P" trackId="0" reactomeId="909679" /> <org.gk.render.RenderableFeature relativeX="0.2831858407079646" relativeY="0.0" label="P" trackId="0" reactomeId="909677" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="16213" reactomeId="877348" position="941 3362" bounds="921 3351 40 23" textPosition="921 3351"> <Properties> <displayName>TYK2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="16214" reactomeId="113592" position="932 3440" bounds="912 3425 40 31" textPosition="916 3429" /> <org.gk.render.RenderableChemical id="16215" reactomeId="29370" position="1108 3455" bounds="1088 3440 41 31" textPosition="1092 3444" /> <org.gk.render.RenderableProtein id="16216" reactomeId="447125" position="1095 3609" bounds="1078 3598 34 23" textPosition="1078 3598"> <Properties> <displayName>IL10</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="16217" reactomeId="448460" position="969 3611" bounds="952 3600 34 23" textPosition="952 3600"> <Properties> <displayName>IL22</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="16370" reactomeId="29370" position="1315 3452" bounds="1295 3437 41 31" textPosition="1299 3441" /> <org.gk.render.RenderableEntitySet id="16371" reactomeId="9850939" position="1424 3456" bounds="1377 3437 95 39" textPosition="1379 3438"> <Properties> <displayName>pY,pS STAT1, STAT3</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="16395" reactomeId="9850892" position="1069 2827" bounds="1038 2816 62 23" textPosition="1038 2816"> <Properties> <displayName>MAPK8,9</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="16396" reactomeId="113592" position="1056 2898" bounds="1036 2883 40 31" textPosition="1040 2887" /> <org.gk.render.RenderableEntitySet id="16398" reactomeId="9850928" position="1301 3059" bounds="1258 3044 87 31" textPosition="1271 3042" /> <org.gk.render.RenderableProtein id="16421" reactomeId="450237" position="1669 3022" bounds="1632 3003 75 38" textPosition="1640 3004"> <Properties> <displayName>p-S63,S73-JUN</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.21333333333333335" relativeY="0.0" label="P" trackId="0" reactomeId="168361" /> <org.gk.render.RenderableFeature relativeX="0.4266666666666667" relativeY="0.0" label="P" trackId="0" reactomeId="450265" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="16422" reactomeId="113582" position="1412 2989" bounds="1393 2977 38 24" textPosition="1396 2978" /> <org.gk.render.RenderableChemical id="16424" reactomeId="29358" position="1413 3116" bounds="1393 3101 40 31" textPosition="1397 3105" /> <org.gk.render.RenderableProtein id="16425" reactomeId="450250" position="1490 3115" bounds="1468 3102 45 26" textPosition="1476 3104"> <Properties> <displayName>JUN</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="16431" reactomeId="3786256" position="1682 3084" bounds="1645 3058 75 52" textPosition="1651 3085"> <Properties> <displayName>CDKN1A gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="16432" reactomeId="182585" position="1818 3061" bounds="1789 3050 59 23" textPosition="1789 3050"> <Properties> <displayName>CDKN1A</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="16438" reactomeId="29370" position="1162 2809" bounds="1142 2794 41 31" textPosition="1146 2798" /> <org.gk.render.RenderableEntitySet id="16439" reactomeId="9850925" position="1137 3060" bounds="1101 3042 73 36" textPosition="1107 3042"> <Properties> <displayName>p-T,Y MAPK8,9</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="16618" reactomeId="198644" position="625 2984" bounds="602 2973 46 23" textPosition="602 2973"> <Properties> <displayName>MDM2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="16619" reactomeId="113592" position="621 2920" bounds="601 2905 40 31" textPosition="605 2909" /> <org.gk.render.RenderableChemical id="16620" reactomeId="29370" position="750 2915" bounds="730 2900 41 31" textPosition="734 2904"> <Properties> <displayName>ADP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="16621" reactomeId="198638" position="769 2999" bounds="718 2979 103 40" textPosition="722 2981"> <Properties> <displayName>p-S166,S188-MDM2</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.16842105263157894" relativeY="0.0" label="P" trackId="0" reactomeId="2399939" /> <org.gk.render.RenderableFeature relativeX="0.3368421052631579" relativeY="0.0" label="P" trackId="0" reactomeId="2399935" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="16622" reactomeId="9850898" position="683 2781" bounds="618 2756 131 51" textPosition="618 2757" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer:PI3K</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="16659" reactomeId="3222171" position="1596 2864" bounds="1546 2845 101 39" textPosition="1548 2848" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S15,S20-TP53 Tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="16664" reactomeId="9850930" position="1727 2945" bounds="1675 2927 104 37" textPosition="1675 2928" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-T,Y MAPK8,9:TP53 tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="16761" reactomeId="6806003" position="767 3152" bounds="685 3118 165 69" textPosition="702 3123"> <Properties> <displayName>Regulation of TP53 Expression and Degradation</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableComplex id="16769" reactomeId="6804449" position="1810 2867" bounds="1768 2843 84 49" textPosition="1775 2856" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Ub:p-S15,S20-TP53</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="16813" reactomeId="453279" position="1482 2386" bounds="1399 2355 166 63" textPosition="1410 2364"> <Properties> <displayName>Mitotic G1 phase and G1/S transition</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableGene id="16907" reactomeId="9008901" position="1478 2165" bounds="1438 2139 80 52" textPosition="1438 2166"> <Properties> <displayName>PTPN6 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableChemical id="16908" reactomeId="113592" position="1369 3317" bounds="1349 3302 40 31" textPosition="1353 3306" /> <org.gk.render.RenderableEntitySet id="16909" reactomeId="1112559" position="1284 3315" bounds="1238 3304 93 23" textPosition="1238 3304"> <Properties> <displayName>STAT1, STAT3</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="17177" reactomeId="68642" position="1294 2477" bounds="1278 2466 32 23" textPosition="1278 2466"> <Properties> <displayName>RB1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="17178" reactomeId="188389" position="1486 2472" bounds="1419 2452 135 41" textPosition="1419 2454"> <Properties> <displayName>hyperphosphorylated RB1</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.11851851851851852" relativeY="0.0" label="P" trackId="0" reactomeId="69225" /> <org.gk.render.RenderableFeature relativeX="0.23703703703703705" relativeY="0.0" label="P" trackId="0" reactomeId="9687341" /> <org.gk.render.RenderableFeature relativeX="0.35555555555555557" relativeY="0.0" label="P" trackId="0" reactomeId="9687344" /> <org.gk.render.RenderableFeature relativeX="0.4740740740740741" relativeY="0.0" label="P" trackId="0" reactomeId="9687333" /> <org.gk.render.RenderableFeature relativeX="0.5925925925925926" relativeY="0.0" label="P" trackId="0" reactomeId="9687337" /> <org.gk.render.RenderableFeature relativeX="0.7111111111111111" relativeY="0.0" label="P" trackId="0" reactomeId="9687359" /> <org.gk.render.RenderableFeature relativeX="0.8296296296296296" relativeY="0.0" label="P" trackId="0" reactomeId="9687345" /> <org.gk.render.RenderableFeature relativeX="1.0" relativeY="0.3902439024390244" label="P" trackId="0" reactomeId="9687338" /> <org.gk.render.RenderableFeature relativeX="0.8814814814814815" relativeY="1.0" label="P" trackId="0" reactomeId="9687346" /> <org.gk.render.RenderableFeature relativeX="0.762962962962963" relativeY="1.0" label="P" trackId="0" reactomeId="9687358" /> <org.gk.render.RenderableFeature relativeX="0.6444444444444445" relativeY="1.0" label="P" trackId="0" reactomeId="9687342" /> <org.gk.render.RenderableFeature relativeX="0.5259259259259259" relativeY="1.0" label="P" trackId="0" reactomeId="9687360" /> <org.gk.render.RenderableFeature relativeX="0.4074074074074074" relativeY="1.0" label="P" trackId="0" reactomeId="9687350" /> <org.gk.render.RenderableFeature relativeX="0.28888888888888886" relativeY="1.0" label="P" trackId="0" reactomeId="9687349" /> </NodeAttachments> </org.gk.render.RenderableProtein> </Nodes> <Edges> <org.gk.render.RenderableReaction id="7" reactomeId="201486" points="251 1862, 272 1881, 289 1912" position="272 1881" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="8" points="218 1857" /> <Input id="9" points="171 247, 144 609" /> </Inputs> <Outputs> <Output id="10" /> </Outputs> <Properties> <displayName>ALK binds ligand pleiotrophin (PTN)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="11" reactomeId="9667914" points="165 1873, 189 1929, 223 1950" position="189 1929" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="12" points="149 1863" /> <Input id="9" points="168 247, 100 475, 126 1699" /> </Inputs> <Outputs> <Output id="13" /> </Outputs> <Properties> <displayName>ALK binds ligand midkine (MDK)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="27" reactomeId="201519" points="301 2119, 305 2145, 342 2219" position="305 2145" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="10" points="295 1941, 302 2059" /> <Input id="15587" points="232 2065" /> </Inputs> <Outputs> <Output id="28" /> </Outputs> <Properties> <displayName>ALK:PTN dimerization</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="29" reactomeId="9700137" points="230 2164, 232 2199, 246 2248" position="232 2199" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="13" points="232 1979, 168 2076" /> <Input id="15587" points="214 2069" /> </Inputs> <Outputs> <Output id="30" /> </Outputs> <Properties> <displayName>ALK:MDK dimerization</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="93" points="261 2277, 323 2332" position="292 2304" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="30" /> </Inputs> <Outputs> <Output id="92" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="94" points="347 2248, 342 2332" position="344 2290" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="28" /> </Inputs> <Outputs> <Output id="92" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="103" reactomeId="201521" points="840 351, 911 350, 941 350" position="911 350" lineWidth="1.0"> <Inputs> <Input id="15519" stoichiometry="6" points="821 380" /> <Input id="15520" points="807 350" /> </Inputs> <Outputs> <Output id="15541" points="1183 340" /> <Output id="15544" stoichiometry="6" points="963 372" /> </Outputs> <Catalysts> <Catalyst id="15520" points="798 325, 845 315" /> </Catalysts> <Inhibitors> <Inhibitor id="413" points="919 318" /> </Inhibitors> <Properties> <displayName>ALK autophosphorylation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="106" reactomeId="9700200" points="333 2517, 329 2499, 330 2459" position="329 2499" lineWidth="1.0"> <Inputs> <Input id="96" points="344 2581" /> <Input id="107" stoichiometry="6" points="424 2543" /> </Inputs> <Outputs> <Output id="92" points="339 2381" /> <Output id="108" stoichiometry="6" points="381 2413" /> </Outputs> <Catalysts> <Catalyst id="109" points="241 2375" /> </Catalysts> <Inhibitors> <Inhibitor id="116" points="258 2551" /> </Inhibitors> <Properties> <displayName>PTPRZ dephosphorylates ligand-bound ALK dimers</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="115" reactomeId="9700121" points="225 2480, 217 2520, 227 2551" position="217 2520" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="114" stoichiometry="6" /> </Inputs> <Outputs> <Output id="116" /> </Outputs> <Properties> <displayName>(PTN,MDK):PTPRZ oligomerizes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="174" reactomeId="9700156" points="1472 445, 1493 440, 1510 402" position="1493 440" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="175" points="1445 466" /> <Input id="15541" points="1256 357, 1377 447" /> </Inputs> <Outputs> <Output id="176" /> </Outputs> <Properties> <displayName>Active ALK dimer binds IRS1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="177" reactomeId="9700168" points="1583 402, 1600 393, 1680 393" position="1600 393" lineWidth="1.0"> <Inputs> <Input id="178" points="1603 424" /> <Input id="176" points="1567 397" /> </Inputs> <Outputs> <Output id="179" points="1734 392" /> <Output id="180" points="1701 424" /> </Outputs> <Catalysts> <Catalyst id="176" points="1553 373, 1598 362" /> </Catalysts> <Properties> <displayName>Active ALK phosphorylates IRS1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="181" reactomeId="9700154" points="1448 545, 1717 533, 1953 375" position="1717 533" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="15541" points="1253 357" /> <Input id="182" points="1413 553" /> </Inputs> <Outputs> <Output id="183" /> </Outputs> <Properties> <displayName>Active ALK binds SHC1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="184" reactomeId="9700175" points="2064 363, 2087 361, 2109 359" position="2087 361" lineWidth="1.0"> <Inputs> <Input id="185" stoichiometry="3" points="2039 388" /> <Input id="183" points="2025 361, 2045 362" /> </Inputs> <Outputs> <Output id="186" points="2166 356" /> <Output id="187" stoichiometry="3" points="2135 393" /> </Outputs> <Catalysts> <Catalyst id="183" points="1986 346, 2027 321" /> </Catalysts> <Properties> <displayName>Active ALK phosphorylates SHC1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="193" interactionType="Activate" points="1829 407, 2083 494" position="1956 450" lineWidth="2.0"> <Inputs> <Input id="179" /> </Inputs> <Outputs> <Output id="191" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="195" interactionType="Activate" points="2213 377, 2161 484" position="2187 430" lineWidth="2.0"> <Inputs> <Input id="186" /> </Inputs> <Outputs> <Output id="191" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="220" reactomeId="9700142" points="1425 340, 1445 340, 1472 338" position="1445 340" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="15541" points="1302 339" /> <Input id="221" points="1403 400" /> </Inputs> <Outputs> <Output id="222" /> </Outputs> <Properties> <displayName>Active ALK binds FRS2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="226" reactomeId="9700164" points="1664 337, 1700 337, 1719 338" position="1700 337" lineWidth="1.0"> <Inputs> <Input id="222" points="1579 336, 1624 337" /> <Input id="178" stoichiometry="6" points="1623 424" /> </Inputs> <Outputs> <Output id="228" points="1739 335" /> <Output id="180" stoichiometry="6" points="1712 424" /> </Outputs> <Catalysts> <Catalyst id="222" points="1564 321, 1664 295" /> </Catalysts> <Properties> <displayName>Active ALK phosphorylates FRS2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="295" reactomeId="201515" points="736 478, 481 480, 288 479" position="481 480" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="296" points="810 485" /> <Input id="15541" points="1200 357" /> </Inputs> <Outputs> <Output id="297" /> </Outputs> <Properties> <displayName>Active ALK recruits PI3K</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="307" reactomeId="201510" points="267 596, 271 630, 272 650" position="271 630" lineWidth="1.0"> <Inputs> <Input id="14466" points="274 554" /> <Input id="14467" points="376 555" /> </Inputs> <Outputs> <Output id="310" points="271 703" /> <Output id="311" points="347 664" /> </Outputs> <Catalysts> <Catalyst id="297" points="231 494, 194 598" /> </Catalysts> <Properties> <displayName>PI3K synthesizes PIP3 downstream of ALK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="326" interactionType="Activate" points="315 720, 723 719" position="519 719" lineWidth="2.0"> <Inputs> <Input id="310" /> </Inputs> <Outputs> <Output id="321" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="336" reactomeId="9700149" points="270 774, 264 810, 261 852" position="264 810" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="337" points="311 782" /> <Input id="310" points="270 740" /> <Input id="15541" points="1216 357" /> </Inputs> <Outputs> <Output id="338" /> </Outputs> <Properties> <displayName>Active ALK binds PLCG1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="339" reactomeId="9700171" points="277 1044, 276 1109, 279 1156" position="276 1109" lineWidth="1.0"> <Inputs> <Input id="340" stoichiometry="4" points="336 998" /> <Input id="338" points="262 881" /> </Inputs> <Outputs> <Output id="348" stoichiometry="4" points="369 1159" /> <Output id="341" points="280 1248" /> </Outputs> <Catalysts> <Catalyst id="338" points="257 881, 226 979" /> </Catalysts> <Properties> <displayName>Active ALK phosphorylates PLCG1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="354" interactionType="Activate" points="337 1281, 408 1299" position="372 1290" lineWidth="2.0"> <Inputs> <Input id="341" /> </Inputs> <Outputs> <Output id="352" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="355" reactomeId="9700648" points="1353 677, 1446 719, 2100 709" position="1446 719" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="356" points="1337 674" /> <Input id="15541" points="1245 357" /> </Inputs> <Outputs> <Output id="357" /> </Outputs> <Properties> <displayName>Active ALK binds SRC</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="358" reactomeId="9700647" points="2164 764, 2166 791, 2167 821" position="2166 791" lineWidth="1.0"> <Inputs> <Input id="359" points="2189 754" /> <Input id="357" points="2152 724" /> </Inputs> <Outputs> <Output id="360" points="2171 900" /> <Output id="361" points="2195 830" /> </Outputs> <Catalysts> <Catalyst id="357" points="2136 724, 2101 752" /> </Catalysts> <Properties> <displayName>Active ALK phosphorylates SRC</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="13574" reactomeId="9700179" points="1428 909, 1473 908, 1491 907" position="1473 908" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="13575" stoichiometry="2" /> </Inputs> <Outputs> <Output id="13576" /> </Outputs> <Properties> <displayName>Ligand-independent dimerization of ALK fusions</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="13577" reactomeId="9700181" points="1659 904, 1684 904, 1707 902" position="1684 904" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="13578" stoichiometry="3" points="1639 928" /> <Input id="13576" points="1621 905" /> </Inputs> <Outputs> <Output id="13579" points="1730 901" /> <Output id="13580" stoichiometry="3" points="1730 946" /> </Outputs> <Catalysts> <Catalyst id="13576" points="1612 883, 1648 877" /> </Catalysts> <Properties> <displayName>Autophosphorylation of ALK fusions</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="13584" reactomeId="9700184" points="391 195, 465 168, 543 190" position="465 168" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="13612" stoichiometry="2" /> </Inputs> <Outputs> <Output id="13614" /> </Outputs> <Properties> <displayName>Ligand-independent dimerization of point mutants of ALK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="13587" reactomeId="9700190" points="1741 727, 1761 731, 1789 755" position="1761 731" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="14784" points="1705 749" /> <Input id="182" points="1410 588" /> </Inputs> <Outputs> <Output id="13588" /> </Outputs> <Properties> <displayName>ALK mutants bind SHC</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="13589" reactomeId="9700193" points="1897 774, 1916 773, 1933 766" position="1916 773" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="13590" stoichiometry="3" points="1876 809" /> <Input id="13588" points="1874 774" /> </Inputs> <Outputs> <Output id="13592" stoichiometry="3" points="1956 803" /> <Output id="13591" points="1955 764" /> </Outputs> <Catalysts> <Catalyst id="13588" points="1844 755, 1894 732" /> </Catalysts> <Properties> <displayName>ALK mutants phosphorylate SHC1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="13596" reactomeId="9700186" points="698 194, 728 193, 761 191" position="728 193" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="13618" stoichiometry="14" points="687 246" /> <Input id="13614" points="658 203" /> </Inputs> <Outputs> <Output id="13621" stoichiometry="14" points="812 237" /> <Output id="13622" points="842 199" /> </Outputs> <Catalysts> <Catalyst id="13614" points="623 190, 705 141" /> </Catalysts> <Properties> <displayName>Autophosphorylation of point mutants of ALK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="13881" reactomeId="9701488" points="324 1640, 322 1667, 322 1696" position="322 1667" lineWidth="1.0"> <Inputs> <Input id="13882" points="316 1552" /> <Input id="13883" points="353 1614" /> </Inputs> <Outputs> <Output id="13884" points="347 1701" /> <Output id="13885" points="324 1746" /> </Outputs> <Catalysts> <Catalyst id="13882" points="309 1552, 272 1626" /> </Catalysts> <Properties> <displayName>Active ALK phosphorylates JAK3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="13886" reactomeId="9701485" points="536 1405, 464 1451, 334 1523" position="464 1451" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="13887" points="628 1450" /> <Input id="15541" points="1239 357, 1136 856" /> </Inputs> <Outputs> <Output id="13882" /> </Outputs> <Properties> <displayName>Active ALK binds JAK3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="13891" reactomeId="9701507" points="415 1718, 421 1634, 419 1592" position="421 1634" lineWidth="1.0"> <Inputs> <Input id="13892" points="435 1733" /> <Input id="13885" points="358 1746" /> </Inputs> <Outputs> <Output id="13882" points="336 1552" /> <Output id="13896" points="455 1576" /> </Outputs> <Catalysts> <Catalyst id="13894" points="459 1634" /> </Catalysts> <Properties> <displayName>PTPN6 dephosphorylates JAK3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="13897" reactomeId="9701524" points="1129 1137, 1094 1267, 1091 1306" position="1094 1267" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="13898" points="970 1174" /> <Input id="15541" points="1240 357" /> </Inputs> <Outputs> <Output id="13907" /> </Outputs> <Properties> <displayName>STAT3 is phosphorylated downstream of active ALK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="13977" reactomeId="9701525" points="1089 1349, 1088 1451, 1093 1631" position="1088 1451" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="13907" stoichiometry="2" /> </Inputs> <Outputs> <Output id="13978" /> </Outputs> <Properties> <displayName>p-Y705,S727-STAT3 dimerizes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="13979" reactomeId="9701529" points="1145 1651, 1417 1647, 1607 1633" position="1417 1647" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="13978" /> </Inputs> <Outputs> <Output id="13980" /> </Outputs> <Properties> <displayName>p-Y705, p-S727 STAT3 dimer translocates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14088" reactomeId="9701531" points="1785 1653, 1844 1654, 1878 1653" position="1844 1654" lineWidth="1.0"> <Inputs> <Input id="13980" points="1709 1638" /> <Input id="14034" points="1781 1665" /> </Inputs> <Outputs> <Output id="14015" points="1922 1642" /> <Output id="14035" points="1913 1681" /> </Outputs> <Catalysts> <Catalyst id="14036" points="1844 1633" /> </Catalysts> <Properties> <displayName>p-Y705,S727 STAT3 is acetylated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14089" reactomeId="9701565" points="1897 1573, 1859 1571, 1811 1571" position="1859 1571" lineWidth="1.0"> <Inputs> <Input id="14015" points="1947 1599" /> <Input id="14090" points="1924 1542" /> </Inputs> <Outputs> <Output id="14054" points="1780 1550" /> <Output id="13980" points="1705 1609" /> </Outputs> <Catalysts> <Catalyst id="14087" points="1856 1506" /> </Catalysts> <Properties> <displayName>HDACs deacetylate p-STAT3 dimers</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14091" reactomeId="9701549" points="2120 1501, 2169 1523, 2209 1525" position="2169 1523" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="14015" points="2001 1599" /> <Input id="14017" points="2072 1444" /> <Input id="14016" points="2091 1553" /> </Inputs> <Outputs> <Output id="14018" /> </Outputs> <Properties> <displayName>AcK685-p-Y705,S727 STAT3 and SIN3A bind the PDRM1 promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14092" reactomeId="9701548" points="2072 1444, 2240 1456, 2339 1463" position="2240 1456" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="14017" /> </Inputs> <Outputs> <Output id="14020" /> </Outputs> <Inhibitors> <Inhibitor id="14018" points="2265 1501" /> </Inhibitors> <Properties> <displayName>PRDM1 gene expression downstream of ALK signaling</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14094" reactomeId="9701556" points="2215 1615, 2562 1640, 2981 1635" position="2562 1640" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="14069" /> </Inputs> <Outputs> <Output id="14078" /> </Outputs> <Inhibitors> <Inhibitor id="14070" points="2557 1605" /> <Inhibitor id="15838" points="2562 1692" /> </Inhibitors> <Properties> <displayName>IL2RG gene expression downstream of ALK signaling</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14095" reactomeId="9701534" points="1484 1522, 1454 1476, 1525 1342" position="1454 1476" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="13980" points="1628 1609" /> <Input id="14083" points="1623 1446, 1564 1426, 1516 1429" /> </Inputs> <Outputs> <Output id="14084" /> </Outputs> <Properties> <displayName>p-Y705, S727 STAT3 dimer binds HIF1A gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14096" reactomeId="9701569" points="1623 1446, 1654 1458, 1680 1458" position="1654 1458" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="14083" /> </Inputs> <Outputs> <Output id="14086" /> </Outputs> <Activators> <Activator id="14084" points="1590 1342, 1645 1366" /> </Activators> <Properties> <displayName>ALK- and STAT3-dependent HIF1A gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14097" reactomeId="9701537" points="2055 1324, 2126 1324, 2176 1321" position="2126 1324" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="14098" points="2017 1370" /> <Input id="13980" points="1668 1609, 1831 1322" /> </Inputs> <Outputs> <Output id="14099" /> </Outputs> <Properties> <displayName>p-Y705, S727 STAT3 dimer binds CD274 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14100" reactomeId="9701562" points="2017 1370, 2254 1385, 2976 1387" position="2254 1385" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="14098" /> </Inputs> <Outputs> <Output id="14101" /> </Outputs> <Activators> <Activator id="14099" points="2249 1348" /> </Activators> <Properties> <displayName>CD274 gene expression downstream of ALK signaling</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14229" reactomeId="9710914" points="1797 1067, 1825 1067, 1852 1065" position="1825 1067" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="14230" points="1784 1062" /> <Input id="14232" points="1744 1085" /> </Inputs> <Outputs> <Output id="14233" /> </Outputs> <Properties> <displayName>ALK fusions bind GRB2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="14231" points="1760 985, 1782 925" position="1771 955" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="14230" /> </Inputs> <Outputs> <Output id="13579" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="14234" reactomeId="9710917" points="480 806, 446 842, 374 900" position="446 842" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="14230" points="1678 1008, 1470 963" /> <Input id="310" points="309 740" /> <Input id="337" points="364 790" /> </Inputs> <Outputs> <Output id="14236" /> </Outputs> <Properties> <displayName>ALK fusion proteins bind PLCG1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14426" reactomeId="9712086" points="315 1039, 316 1085, 325 1121" position="316 1085" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="14236" points="337 957" /> <Input id="340" stoichiometry="4" points="346 1003" /> </Inputs> <Outputs> <Output id="14429" points="360 1185" /> <Output id="348" stoichiometry="4" points="369 1148" /> </Outputs> <Catalysts> <Catalyst id="14236" points="374 957, 457 1022" /> </Catalysts> <Properties> <displayName>ALK fusions phosphorylate PLCG1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="14434" interactionType="Activate" points="387 1228, 441 1283" position="414 1255" lineWidth="2.0"> <Inputs> <Input id="14429" /> </Inputs> <Outputs> <Output id="352" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="14561" reactomeId="9712083" points="529 614, 506 617, 477 619" position="506 617" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="14562" points="556 592" /> <Input id="14570" points="715 608" /> </Inputs> <Outputs> <Output id="14564" /> </Outputs> <Properties> <displayName>ALK mutants bind PI3KCA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14565" reactomeId="9712078" points="888 599, 872 600, 848 601" position="872 600" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="14566" points="939 585" /> <Input id="14567" points="921 632" /> </Inputs> <Outputs> <Output id="14570" /> </Outputs> <Properties> <displayName>ALK mutants bind PI3KR1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14574" reactomeId="9712084" points="319 590, 319 629, 311 673" position="319 629" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="14466" points="288 554" /> <Input id="14467" points="376 558" /> </Inputs> <Outputs> <Output id="310" points="283 703" /> <Output id="311" points="347 669" /> </Outputs> <Catalysts> <Catalyst id="14564" points="356 626" /> </Catalysts> <Properties> <displayName>PI3K synthesizes PIP3 downstream of ALK mutants</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14601" reactomeId="9712081" points="1630 650, 1687 648, 1730 650" position="1687 648" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="15475" points="1534 658" /> <Input id="14602" points="1602 624" /> </Inputs> <Outputs> <Output id="14607" /> </Outputs> <Properties> <displayName>ALK fusions bind FRS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14608" reactomeId="9712087" points="1867 656, 1885 655, 1901 653" position="1885 655" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="14607" points="1835 655" /> <Input id="14711" stoichiometry="6" points="1805 617" /> </Inputs> <Outputs> <Output id="14611" points="1974 654" /> <Output id="14712" stoichiometry="6" points="1895 614" /> </Outputs> <Catalysts> <Catalyst id="14607" points="1813 669, 1873 687" /> </Catalysts> <Properties> <displayName>ALK fusions phosphorylate FRS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14708" reactomeId="9712088" points="1508 573, 1605 572, 1645 570" position="1605 572" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="175" points="1442 495" /> <Input id="15475" points="1479 633" /> </Inputs> <Outputs> <Output id="14709" /> </Outputs> <Properties> <displayName>ALK fusion proteins bind IRS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14710" reactomeId="9712082" points="1794 563, 1821 561, 1852 561" position="1821 561" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="14711" points="1786 588" /> <Input id="14709" points="1745 566" /> </Inputs> <Outputs> <Output id="14712" points="1874 577" /> <Output id="14713" points="1925 562" /> </Outputs> <Catalysts> <Catalyst id="14709" points="1736 548, 1814 516" /> </Catalysts> <Properties> <displayName>ALK fusions phosphorylate IRS1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14773" reactomeId="9712079" points="911 1678, 912 1697, 916 1725" position="912 1697" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="14774" points="855 1643" /> <Input id="13898" points="942 1195" /> </Inputs> <Outputs> <Output id="14779" /> </Outputs> <Properties> <displayName>ALK mutants bind STAT3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="14777" points="855 1594, 1764 925" position="1309 1259" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="14774" /> </Inputs> <Outputs> <Output id="13579" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="14780" reactomeId="9712085" points="931 1788, 932 1816, 934 1836" position="932 1816" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="14779" points="924 1768" /> <Input id="14781" stoichiometry="2" points="997 1781" /> </Inputs> <Outputs> <Output id="14782" points="933 1880" /> <Output id="14783" stoichiometry="2" points="885 1847" /> </Outputs> <Catalysts> <Catalyst id="14779" points="902 1768, 873 1797" /> </Catalysts> <Properties> <displayName>ALK mutants phosphorylate STAT3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="14832" points="1503 696, 1763 876" position="1633 786" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="15475" /> </Inputs> <Outputs> <Output id="13579" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="14846" reactomeId="9701903" points="1339 1945, 1442 1946, 1489 1947" position="1442 1946" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="14837" /> </Inputs> <Outputs> <Output id="14847" /> </Outputs> <Inhibitors> <Inhibitor id="14839" points="1479 1892" /> </Inhibitors> <Properties> <displayName>ALK-, STAT3- and MECP2-dependent STAT5A gene repression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14872" reactomeId="9724090" points="1496 1084, 1527 1087, 1536 1087" position="1527 1087" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="14873" /> </Inputs> <Outputs> <Output id="14874" /> </Outputs> <Properties> <displayName>MYH9- and RNF213-ALK fusions are phosphorylated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14925" reactomeId="9724099" points="2003 1097, 2025 1096, 2052 1095" position="2025 1096" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="14232" points="1744 1092" /> <Input id="13591" points="2015 783" /> </Inputs> <Outputs> <Output id="14926" /> </Outputs> <Properties> <displayName>ALK mutants:p-3Y SHC binds GRB2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="15091" points="1001 653, 1093 649, 1016 275, 929 230" position="1054 462" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="14567" /> </Inputs> <Outputs> <Output id="13622" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="15118" points="836 1594, 1129 625, 1029 263, 940 230" position="1079 444" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="14774" /> </Inputs> <Outputs> <Output id="13622" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="15196" points="1619 763, 1361 720, 1110 640, 1020 269, 933 230" position="1110 640" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="14784" /> </Inputs> <Outputs> <Output id="13622" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="15198" points="1697 798, 1772 876" position="1734 837" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="14784" /> </Inputs> <Outputs> <Output id="13579" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="15221" points="1001 672, 1730 884" position="1365 778" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="14567" /> </Inputs> <Outputs> <Output id="13579" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="15258" reactomeId="9725023" points="1449 2602, 1468 2602, 1488 2600" position="1468 2602" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="15259" points="1437 2580" /> <Input id="15260" points="1400 2644" /> </Inputs> <Outputs> <Output id="15261" /> </Outputs> <Properties> <displayName>NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15262" reactomeId="9725030" points="1652 2598, 1676 2599, 1695 2599" position="1676 2599" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="15261" points="1619 2598" /> <Input id="15263" points="1637 2570" /> </Inputs> <Outputs> <Output id="15264" points="1724 2598" /> <Output id="15265" points="1716 2556" /> </Outputs> <Catalysts> <Catalyst id="15266" points="1679 2512" /> </Catalysts> <Properties> <displayName>MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="15271" interactionType="Activate" points="2214 517, 3087 540, 3160 2481, 1730 2489" position="3123 1510" lineWidth="2.0"> <Inputs> <Input id="191" /> </Inputs> <Outputs> <Output id="15266" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="15274" reactomeId="9725009" points="1166 2676, 1235 2679, 1305 2675" position="1235 2679" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="15275" /> </Inputs> <Outputs> <Output id="15260" /> </Outputs> <Activators> <Activator id="15276" points="1140 2575" /> </Activators> <Properties> <displayName>NPM1-ALK translocates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15283" reactomeId="9725117" points="1311 1537, 1068 1508, 827 1521, 24 1478, 28 232, 154 232" position="1068 1508" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="15284" /> </Inputs> <Outputs> <Output id="9" /> </Outputs> <Activators> <Activator id="15285" points="1266 1461" /> </Activators> <Properties> <displayName>ALK gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15325" reactomeId="9725332" points="1350 1537, 1357 1512, 1331 1471" position="1357 1512" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="15284" points="1311 1537" /> <Input id="15326" points="1374 1538" /> </Inputs> <Outputs> <Output id="15285" /> </Outputs> <Properties> <displayName>MYC/MYCN bind the ALK gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15408" reactomeId="9725342" points="1836 2745, 1920 2749, 2771 2734" position="1920 2749" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="15409" /> </Inputs> <Outputs> <Output id="15434" /> </Outputs> <Activators> <Activator id="15413" points="2003 2720" /> <Activator id="15260" points="1442 2676, 1826 2701" /> </Activators> <Properties> <displayName>NPM1-ALK-dependent JUNB gene transcription</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="15415" interactionType="Activate" points="2214 515, 3124 513, 3220 2614, 2115 2700" position="3172 1563" lineWidth="2.0"> <Inputs> <Input id="191" /> </Inputs> <Outputs> <Output id="15413" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="15435" reactomeId="9725345" points="2795 2749, 2664 2832, 2525 2837" position="2664 2832" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="15434" /> </Inputs> <Outputs> <Output id="15410" /> </Outputs> <Activators> <Activator id="15436" points="2818 2828" /> </Activators> <Properties> <displayName>NPM1-ALK-dependent JUNB translation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15460" reactomeId="9725338" points="1523 3163, 1603 3144, 1600 3273" position="1603 3144" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="15461" /> </Inputs> <Outputs> <Output id="15462" /> </Outputs> <Activators> <Activator id="15260" points="1390 2701, 1592 2991" /> </Activators> <Properties> <displayName>NPM1-ALK-dependent BCL2A1 gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15472" reactomeId="9725357" points="1971 2575, 2064 2584, 2167 2576" position="2064 2584" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="15473" /> </Inputs> <Outputs> <Output id="15474" /> </Outputs> <Activators> <Activator id="13980" points="1663 1652, 1834 2245" /> <Activator id="15260" points="1442 2673, 1934 2686" /> <Activator id="15413" points="2060 2673" /> </Activators> <Properties> <displayName>NPM1-ALK-dependent CEBPB gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15480" reactomeId="9700662" points="637 296, 769 297, 863 292" position="769 297" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="15520" points="705 325" /> <Input id="416" points="564 409" /> </Inputs> <Outputs> <Output id="413" /> </Outputs> <Properties> <displayName>Liganded-ALK dimer binds type I ALK-binding TKIs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15513" reactomeId="9842656" points="269 263, 348 289, 444 300" position="348 289" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="15511" points="234 176" /> <Input id="9" stoichiometry="2" points="191 236" /> </Inputs> <Outputs> <Output id="15512" /> </Outputs> <Properties> <displayName>ALK binds ALKAL ligand</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="15521" points="258 2248, 446 1994, 738 374" position="446 1994" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="30" /> </Inputs> <Outputs> <Output id="15520" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="15522" points="357 2219, 492 2052, 739 374" position="492 2052" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="28" /> </Inputs> <Outputs> <Output id="15520" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="15523" points="571 318, 677 338" position="624 328" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="15512" /> </Inputs> <Outputs> <Output id="15520" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndEntitySetLink id="15543" points="1237 357, 354 2581" position="795 1469" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="15541" /> </Inputs> <Outputs> <Output id="96" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="15621" reactomeId="9700120" points="137 2381, 137 2416, 206 2451" position="137 2416" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="15622" points="142 2155" /> <Input id="109" points="183 2367" /> </Inputs> <Outputs> <Output id="114" /> </Outputs> <Properties> <displayName>PTN and MDK bind to PTPRZ</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="15623" points="195 1871, 145 2120" position="170 1995" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="8" /> </Inputs> <Outputs> <Output id="15622" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="15624" points="128 1869, 142 2120" position="135 1994" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="12" /> </Inputs> <Outputs> <Output id="15622" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="15625" reactomeId="9850958" points="992 1889, 1253 1802, 1614 1652" position="1253 1802" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="14782" /> </Inputs> <Outputs> <Output id="13980" /> </Outputs> <Properties> <displayName>pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15653" reactomeId="9851104" points="2257 2394, 2446 2379, 2969 2405" position="2446 2379" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="15631" /> </Inputs> <Outputs> <Output id="15654" /> </Outputs> <Activators> <Activator id="15632" points="2274 2301" /> </Activators> <Properties> <displayName>NPM1-ALK- and STAT3-dependent ICOS gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15671" reactomeId="9851109" points="1695 2377, 1748 2378, 1795 2378" position="1748 2378" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="15672" /> </Inputs> <Outputs> <Output id="15673" /> </Outputs> <Activators> <Activator id="13980" points="1660 1652, 1720 2073" /> </Activators> <Properties> <displayName>NPM1-ALK- and STAT3-dependent TWIST gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15674" reactomeId="9851106" points="1996 2374, 2054 2285, 2185 2285" position="2054 2285" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="15631" points="2257 2394" /> <Input id="13980" points="1666 1652" /> </Inputs> <Outputs> <Output id="15632" /> </Outputs> <Properties> <displayName>p-Y705, S727 STAT3 dimer binds ICOS promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15723" reactomeId="9851118" points="2167 2152, 2248 2135, 2321 2138" position="2248 2135" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="15724" points="2181 2184" /> <Input id="13980" points="1668 1652, 1987 2204" /> </Inputs> <Outputs> <Output id="15726" /> </Outputs> <Properties> <displayName>pY-STAT3 binds the IRF4 promoter downstream of NPM1-ALK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15727" reactomeId="9851117" points="2181 2184, 2395 2206, 2805 2224" position="2395 2206" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="15724" /> </Inputs> <Outputs> <Output id="15728" /> </Outputs> <Activators> <Activator id="15726" points="2392 2163" /> </Activators> <Properties> <displayName>NPM1-ALK- and p-STAT3-dependent IRF4 gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15737" reactomeId="9851090" points="1371 2731, 1370 2750, 1373 2780" position="1370 2750" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="15738" points="1326 2747" /> <Input id="15260" points="1372 2701" /> <Input id="15740" points="1325 2719" /> </Inputs> <Outputs> <Output id="15741" /> </Outputs> <Properties> <displayName>NPM1-ALK binds NPM1 and FOXM1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15746" reactomeId="9851092" points="1339 2863, 1376 2859, 1429 2861" position="1376 2859" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="15747" /> </Inputs> <Outputs> <Output id="15748" /> </Outputs> <Activators> <Activator id="15741" points="1375 2823" /> </Activators> <Properties> <displayName>NPM1-ALK and FOXM1-dependent CCNB1 gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15773" reactomeId="9725315" points="1321 1344, 1334 1346, 1358 1345" position="1334 1346" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="15550" /> </Inputs> <Outputs> <Output id="15551" /> </Outputs> <Activators> <Activator id="15541" points="1243 357" /> </Activators> <Properties> <displayName>ALK-stimulated MYCN gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15782" reactomeId="9851068" points="1748 3146, 1761 3223, 1764 3497" position="1761 3223" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="15783" /> </Inputs> <Outputs> <Output id="15784" /> </Outputs> <Activators> <Activator id="15785" points="1857 3330" /> </Activators> <Properties> <displayName>Crizotinib-driven IL10RA gene expression in NPM1-ALK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="15792" interactionType="Activate" points="1737 3511, 1622 3516" position="1679 3513" lineWidth="2.0"> <Inputs> <Input id="15784" /> </Inputs> <Outputs> <Output id="15790" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="15817" reactomeId="9851122" points="1607 2234, 1503 2223, 1387 2234" position="1503 2223" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="13980" points="1656 1652" /> <Input id="15818" points="1582 2289" /> </Inputs> <Outputs> <Output id="15819" /> </Outputs> <Properties> <displayName>p-Y705,S727 STAT3 dimer binds NOTCH gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15820" reactomeId="9851123" points="1582 2289, 1334 2302, 1029 2306" position="1334 2302" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="15818" /> </Inputs> <Outputs> <Output id="15821" /> </Outputs> <Activators> <Activator id="15819" points="1334 2269" /> </Activators> <Properties> <displayName>NPM1-ALK- and p-STAT3-dependent NOTCH gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15883" reactomeId="9851062" points="2210 2009, 2441 1976, 2508 1976" position="2441 1976" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="15884" points="2217 2062" /> <Input id="14015" points="1990 1642" /> </Inputs> <Outputs> <Output id="15885" /> </Outputs> <Properties> <displayName>AcK685 pY705,S727 STAT3 binds the MIR21 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15890" reactomeId="9851139" points="2217 2062, 2562 2034, 2822 2036" position="2562 2034" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="15884" /> </Inputs> <Outputs> <Output id="15891" /> </Outputs> <Inhibitors> <Inhibitor id="15885" points="2566 2006" /> </Inhibitors> <Properties> <displayName>STAT3-dependent MIR-21 gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15909" reactomeId="9851145" points="2770 1828, 2593 1797, 2268 1785" position="2593 1797" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="15910" /> </Inputs> <Outputs> <Output id="15844" /> </Outputs> <Inhibitors> <Inhibitor id="15911" points="2811 1724" /> </Inhibitors> <Properties> <displayName>Translation of DNMT1 mRNA is repressed by miR-21</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15912" reactomeId="9851147" points="2890 1964, 2936 1909, 2870 1724" position="2936 1909" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="15910" points="2843 1855" /> <Input id="15891" points="2869 2020" /> </Inputs> <Outputs> <Output id="15911" /> </Outputs> <Properties> <displayName>miR-21 RISC binds DNMT1 mRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15925" reactomeId="9851137" points="2322 1810, 2548 1833, 2770 1838" position="2548 1833" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="15926" /> </Inputs> <Outputs> <Output id="15910" /> </Outputs> <Activators> <Activator id="15927" points="2552 1885" /> </Activators> <Properties> <displayName>STAT3-dependent DNMT1 gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15989" reactomeId="9851071" points="1580 2048, 1464 2053, 1396 2048" position="1464 2053" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="13980" points="1654 1652" /> <Input id="15991" points="1476 2011" /> <Input id="15844" points="2209 1795" /> <Input id="16907" points="1527 2141" /> </Inputs> <Outputs> <Output id="15992" /> </Outputs> <Properties> <displayName>STAT3, DNMT1 and HDAC1 bind PTPN6 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15997" reactomeId="9851072" points="1527 2141, 804 2167, 492 1650" position="804 2167" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="16907" /> </Inputs> <Outputs> <Output id="13894" /> </Outputs> <Inhibitors> <Inhibitor id="15992" points="1264 2059" /> </Inhibitors> <Properties> <displayName>DNMT1-dependent PTPN6 gene silencing</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15998" reactomeId="9701557" points="2291 1577, 2331 1575, 2492 1575" position="2331 1575" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="14069" points="2215 1615" /> <Input id="14015" points="2044 1611" /> <Input id="14016" points="2110 1568" /> </Inputs> <Outputs> <Output id="14070" /> </Outputs> <Properties> <displayName>AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="16003" reactomeId="9851058" points="2262 1719, 2324 1716, 2498 1718" position="2324 1716" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="14069" points="2215 1615" /> <Input id="14015" points="2032 1642" /> <Input id="15844" points="2242 1771" /> </Inputs> <Outputs> <Output id="15838" /> </Outputs> <Properties> <displayName>AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="16007" interactionType="Activate" points="2859 2846, 2862 2948" position="2860 2897" lineWidth="2.0"> <Inputs> <Input id="15436" /> </Inputs> <Outputs> <Output id="16005" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="16020" reactomeId="9851064" points="2272 1967, 2434 1931, 2488 1922" position="2434 1931" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="14015" points="1995 1642" /> <Input id="15926" points="2322 1810" /> </Inputs> <Outputs> <Output id="15927" /> </Outputs> <Properties> <displayName>AcK685-pY705,S727 STAT3 dimer binds DNMT1 promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="16061" reactomeId="9851133" points="1898 1819, 1917 1817, 1960 1780" position="1917 1817" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="16062" /> </Inputs> <Outputs> <Output id="16063" /> </Outputs> <Inhibitors> <Inhibitor id="15844" points="2209 1787" /> <Inhibitor id="13980" points="1683 1652" /> </Inhibitors> <Properties> <displayName>STAT3-, DNMT1 and NPM1-ALK-dependent ZAP70 gene silencing</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="16120" reactomeId="9851084" points="2332 2836, 2297 2836, 2256 2837" position="2297 2836" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="16121" points="2412 2907" /> <Input id="15410" stoichiometry="2" points="2482 2837" /> </Inputs> <Outputs> <Output id="16122" /> </Outputs> <Properties> <displayName>JUNB dimer binds GZMB promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="16123" reactomeId="9851088" points="2412 2907, 2203 2936, 2205 3310" position="2203 2936" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="16121" /> </Inputs> <Outputs> <Output id="16124" /> </Outputs> <Activators> <Activator id="16122" points="2198 2861" /> </Activators> <Properties> <displayName>JUNB- and NPM1-ALK-mediated GZMB gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="16126" reactomeId="9851131" points="1969 2917, 2039 2901, 2151 3315" position="2039 2901" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="16127" /> </Inputs> <Outputs> <Output id="16128" /> </Outputs> <Activators> <Activator id="15260" points="1442 2694" /> </Activators> <Properties> <displayName>NPM1-ALK-stimulated PRF1 gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="16181" reactomeId="9851112" points="1374 3155, 1220 3152, 1167 3152" position="1220 3152" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="16182" /> </Inputs> <Outputs> <Output id="16183" /> </Outputs> <Activators> <Activator id="16184" points="1161 3343" /> </Activators> <Properties> <displayName>NPM1-ALK- and TYK2-dependent MCL1 gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="16212" reactomeId="9851114" points="1007 3406, 1037 3405, 1076 3403" position="1037 3405" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="16213" points="958 3377" /> <Input id="16214" stoichiometry="2" points="955 3430" /> </Inputs> <Outputs> <Output id="16184" points="1118 3386" /> <Output id="16215" stoichiometry="2" points="1098 3437" /> </Outputs> <Activators> <Activator id="16216" points="1091 3595" /> <Activator id="16217" points="972 3597" /> <Activator id="15275" points="1082 2704, 971 2897" /> </Activators> <Properties> <displayName>NPM1-ALK-dependent TYK2 phosphorylation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="16229" interactionType="Activate" points="1115 3605, 1491 3531" position="1303 3568" lineWidth="2.0"> <Inputs> <Input id="16216" /> </Inputs> <Outputs> <Output id="15790" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="16366" reactomeId="9851142" points="1322 3352, 1316 3380, 1312 3411" position="1316 3380" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="16908" stoichiometry="2" points="1346 3331" /> <Input id="16909" points="1295 3333" /> </Inputs> <Outputs> <Output id="16370" stoichiometry="2" points="1313 3434" /> <Output id="16371" points="1371 3433" /> </Outputs> <Activators> <Activator id="16184" points="1216 3369" /> </Activators> <Properties> <displayName>TYK2-dependent STAT1 and STAT3 phosphorylation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="16372" points="1092 1349, 1420 3431" position="1256 2390" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="13907" /> </Inputs> <Outputs> <Output id="16371" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="16394" reactomeId="9851078" points="1096 2858, 1115 2861, 1137 2860" position="1115 2861" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="16395" points="1079 2845" /> <Input id="16396" stoichiometry="2" points="1071 2880" /> </Inputs> <Outputs> <Output id="16438" stoichiometry="2" points="1154 2828" /> <Output id="16439" points="1137 3036" /> </Outputs> <Activators> <Activator id="15275" points="1099 2704" /> </Activators> <Properties> <displayName>NPM1-ALK-dependent MAPK8,9 phosphorylation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="16419" reactomeId="9851096" points="1457 3074, 1457 3055, 1457 3032" position="1457 3055" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="16424" stoichiometry="2" points="1429 3098" /> <Input id="16425" points="1479 3099" /> </Inputs> <Outputs> <Output id="16421" points="1629 3023" /> <Output id="16422" stoichiometry="2" points="1424 3004" /> </Outputs> <Activators> <Activator id="16398" points="1351 3057" /> </Activators> <Properties> <displayName>NPM1-ALK- and JNK-dependent JUN phosphorylation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="16430" reactomeId="9851098" points="1729 3060, 1758 3060, 1786 3060" position="1758 3060" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="16431" /> </Inputs> <Outputs> <Output id="16432" /> </Outputs> <Inhibitors> <Inhibitor id="16421" points="1710 3038" /> </Inhibitors> <Properties> <displayName>NPM1-ALK- and JUN-dependent CDKN1A gene repression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="16452" reactomeId="9851079" points="1180 3060, 1214 3061, 1252 3060" position="1214 3061" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="16439" /> </Inputs> <Outputs> <Output id="16398" /> </Outputs> <Properties> <displayName>p-T,Y MAPK8,9 translocate to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="16617" reactomeId="9851102" points="654 2963, 681 2964, 703 2964" position="681 2964" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="16618" points="640 2970" /> <Input id="16619" stoichiometry="2" points="632 2939" /> </Inputs> <Outputs> <Output id="16620" stoichiometry="2" points="735 2934" /> <Output id="16621" points="731 2976" /> </Outputs> <Activators> <Activator id="16622" points="682 2810" /> </Activators> <Properties> <displayName>NPM1-ALK- and PI3K-dependent MDM2 phosphorylation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="16682" reactomeId="9851076" points="1619 2948, 1645 2947, 1672 2946" position="1645 2947" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="16398" points="1315 3038, 1412 2944" /> <Input id="16659" points="1601 2887" /> </Inputs> <Outputs> <Output id="16664" /> </Outputs> <Properties> <displayName>p-T,Y MAPK8,9 bind TP53</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="16763" interactionType="Activate" points="768 3022, 767 3115" position="767 3068" lineWidth="2.0"> <Inputs> <Input id="16621" /> </Inputs> <Outputs> <Output id="16761" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="16906" reactomeId="9701810" points="1345 1884, 1372 1882, 1434 1875" position="1372 1882" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="14837" points="1339 1945" /> <Input id="14838" points="1320 1885" /> </Inputs> <Outputs> <Output id="14839" /> </Outputs> <Activators> <Activator id="13980" points="1637 1652" /> </Activators> <Properties> <displayName>MECP2 binds the STAT5A gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="16910" points="944 1195, 1282 3298" position="1113 2246" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="13898" /> </Inputs> <Outputs> <Output id="16909" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="17163" reactomeId="9851077" points="1650 2864, 1699 2865, 1765 2866" position="1699 2865" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="16659" /> </Inputs> <Outputs> <Output id="16769" /> </Outputs> <Activators> <Activator id="16664" points="1720 2924" /> </Activators> <Properties> <displayName>JNK-dependent inhibition of TP53 ubiquitination</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="17176" reactomeId="9851127" points="1313 2476, 1351 2474, 1416 2473" position="1351 2474" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="17177" /> </Inputs> <Outputs> <Output id="17178" /> </Outputs> <Inhibitors> <Inhibitor id="15260" points="1370 2644" /> </Inhibitors> <Properties> <displayName>NPM1-ALK-dependent repression of pRB phosphorylation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="17180" interactionType="Activate" points="1484 2449, 1483 2421" position="1483 2435" lineWidth="2.0"> <Inputs> <Input id="17178" /> </Inputs> <Outputs> <Output id="16813" /> </Outputs> </org.gk.render.RenderableInteraction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Signaling by ALK, Signaling by ALK fusions and activated point mutants, ALK mutants bind TKIs, ASP-3026- resistant ALK mutants, NVP-TAE684-resistant ALK mutants, alectinib resistant ALK mutants, brigatinib-resistant ALK mutants, ceritinib-resistant ALK mutants, crizotinib-resistant ALK mutants, and lorlatinib-resistant ALK mutants (9700218)
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