Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person PI3K phosphorylates PIP2 to PIP3 downstream of activated ALK...
| Class:Id | Summation:9700203 |
|---|---|
| _displayName | PI3K phosphorylates PIP2 to PIP3 downstream of activated ALK... |
| _timestamp | 2023-10-12 18:29:45 |
| created | [InstanceEdit:9700204] Rothfels, Karen, 2020-09-14 |
| modified | [InstanceEdit:9700676] Rothfels, Karen, 2020-09-16 [InstanceEdit:9702121] Rothfels, Karen, 2020-09-29 [InstanceEdit:9850795] Rothfels, Karen, 2023-10-12 |
| text | PI3K phosphorylates PIP2 to PIP3 downstream of activated ALK, leading to activation of the AKT pathway as assessed by S473 phosphorylation (Bai et al, 2000; Slupianek et al, 2001; Slupianek et al, 2004; Chen et al, 2008). AKT signaling contributes to apoptotic escape and cellular proliferation through regulation of proteins such as CDKN1B/p27, CCND2 and BCL2L11/BIM, among others (Gu et al, 2004; Rassidakis et al, 2005; Marzec et al, 2007; reviewed in Chiarle et al, 2008). |
| (summation) | [Reaction:201510] PI3K synthesizes PIP3 downstream of ALK [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by PI3K phosphorylates PIP2 to PIP3 downstream of activated ALK... (9700203)
