Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person IRS1 is phosphorylated downstream of active ALK in a manner ...
| Class:Id | Summation:9700169 |
|---|---|
| _displayName | IRS1 is phosphorylated downstream of active ALK in a manner ... |
| _timestamp | 2023-10-12 18:29:44 |
| created | [InstanceEdit:9700167] Rothfels, Karen, 2020-09-14 |
| modified | [InstanceEdit:9702119] Rothfels, Karen, 2020-09-29 [InstanceEdit:9850795] Rothfels, Karen, 2023-10-12 |
| text | IRS1 is phosphorylated downstream of active ALK in a manner that is dependent on ALK kinase activity. Based on studies in NPM-ALK fusions, ALK likely phosphorylates IRS1 on one or more tyrosine residues, but the target amino acid(s) have not been identified directly in the context of the full-length ALK receptor (Fujimoto et al 1996; Stoica et al, 2001; Motegi et al, 2004; reviewed in Roskoski, 2013; Delle Corte et al, 2018). ALK-dependent IRS1 phosphorylation activates the MAP kinase signaling pathway and promotes cellular proliferation, but direct binding of a RAS GEF such as GRB2:SOS1 has not been shown (reviewed in Turner and Alexander, 2006; Chiarle et al, 2008; Roskoski, 2013). |
| (summation) | [Reaction:9700168] Active ALK phosphorylates IRS1 [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by IRS1 is phosphorylated downstream of active ALK in a manner ... (9700169)
