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| Class:Id | Summation:9700123 |
|---|---|
| _displayName | PTN- and MDK-binding to the chondroitin sulphate moieties of... |
| _timestamp | 2020-09-14 13:20:53 |
| created | [InstanceEdit:9700122] Rothfels, Karen, 2020-09-14 |
| text | PTN- and MDK-binding to the chondroitin sulphate moieties of PTPRZ promote oligomerization of the phosphatase, possibly by neutralizing the negative charge of the glycan group. Oligomerization of PTPRZ inactivates the enzyme, resulting in the accumulation of tyrosine-phosphorylated ALK and increased ALK-dependent signaling (Fukada et al, 2006; Kuboyama et al, 2016). |
| (summation) | [Reaction:9700121] (PTN,MDK):PTPRZ oligomerizes [Homo sapiens] |
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