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Details on Person quizartinib-sensitive FLT3 mutants [plasma membrane]

Class:IdDefinedSet:9699531
_displayNamequizartinib-sensitive FLT3 mutants [plasma membrane]
_timestamp2020-10-03 01:54:07
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9699524] Rothfels, Karen, 2020-09-14
disease[Disease:1500689] cancer
hasMember
literatureReference[LiteratureReference:9699282] FLT3 and FLT3-ITD phosphorylate and inactivate the cyclin-dependent kinase inhibitor p27Kip1 in acute myeloid leukemia
[LiteratureReference:9699248] Crenolanib is a potent inhibitor of FLT3 with activity against resistance-conferring point mutants
[LiteratureReference:9699345] Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors
[LiteratureReference:9699359] Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns
[LiteratureReference:9702954] FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors
modified[InstanceEdit:9702941] Rothfels, Karen, 2020-10-02
[InstanceEdit:9703028] Rothfels, Karen, 2020-10-03
namequizartinib-sensitive FLT3 mutants
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9699560] R-HSA-9699531.1
(hasMember)[DefinedSet:9702524] type II TKI sensitive FLT3 mutants [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by quizartinib-sensitive FLT3 mutants [plasma membrane] (9699531)
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