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Details on Person FLT3 E596_Y597insRTDFRE [plasma membrane]

Class:Id	EntityWithAccessionedSequence:9699428
_displayName	FLT3 E596_Y597insRTDFRE [plasma membrane]
_timestamp	2020-09-14 12:24:07
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9699450] Rothfels, Karen, 2020-09-14
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
endCoordinate	993
hasModifiedResidue	[FragmentReplacedModification:9699418] Replacement of residues 596 to 597 by ERTDFREY
literatureReference	[LiteratureReference:9699329] Inhibition of the transforming activity of FLT3 internal tandem duplication mutants from AML patients by a tyrosine kinase inhibitor
modified	[InstanceEdit:9832487] Orlic-Milacic, Marija, 2023-04-01
name	FLT3 E596_Y597insRTDFRE ITD1
referenceEntity	[ReferenceGeneProduct:54914] UniProt:P36888 FLT3 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9699461] R-HSA-9699428.2
startCoordinate	27
(hasComponent)	[Complex:9699483] FLT3 E596_Y597insRTDFRE dimer [plasma membrane] [Homo sapiens]
(hasMember)	[CandidateSet:9691152] juxtamembrane domain mutants of FLT3 [plasma membrane] [Homo sapiens] [DefinedSet:9699522] sorafenib-sensitive FLT3 mutants [plasma membrane] [Homo sapiens] [DefinedSet:9699532] sunitinib-sensitive FLT3 mutants [plasma membrane] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9905796] Update Tracker - [EntityWithAccessionedSequence:9699428] FLT3 E596_Y597insRTDFRE [plasma membrane] - v85:[removeHasModifiedResidue]
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No pathways have been reviewed or authored by FLT3 E596_Y597insRTDFRE [plasma membrane] (9699428)