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Query author contributions in Reactome

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Details on Person SARS-CoV-2 virions attached to the host cell surface via a c...

Class:IdSummation:9698991
_displayNameSARS-CoV-2 virions attached to the host cell surface via a c...
_timestamp2022-05-20 08:55:27
created[InstanceEdit:9699008] Gillespie, Marc E, 2020-09-05
literatureReference[LiteratureReference:9698993] A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells
[LiteratureReference:9681513] A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry
[LiteratureReference:9687564] Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2
[LiteratureReference:9687530] Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response
[LiteratureReference:9699000] The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin
modified[InstanceEdit:9752961] Rothfels, Karen, 2021-09-01
[InstanceEdit:9774254] Stephan, Ralf, 2022-05-20
textSARS-CoV-2 virions attached to the host cell surface via a complex involving viral spike (S) protein and host angiotensin-converting enzyme 2 (ACE2) can directly fuse their membrane with the host cell membrane, releasing the uncoated virion nucleocapsid into the cytoplasm. The process starts with the spike protein undergoing cleavage by furin into S1/S2, followed by cleavage of S2 catalyzed by TMPRSS2, freeing the fusion peptide (FP) which mediates membrane fusion. Heparin binding to SARS-CoV-2 spike (S) effectively inhibits its cleavage into S1, S2 by furin. Unfractionated heparin (UFH) exhibits a higher furin inhibitory potency than the low-molecular-weight heparin (LMWH) (Paiardi et al, 2021). However, cleavage at the S1/S2 site occurs to some extent even if furin is absent, presumably due to the action of other proprotein convertases (Papa et al, 2021; Jaimes et al, 2020; reviewed by Takeda, 2022).
(summation)[BlackBoxEvent:9698988] Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid [Homo sapiens]
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No pathways have been reviewed or authored by SARS-CoV-2 virions attached to the host cell surface via a c... (9698991)
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