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Details on Person MLKL binds HSP90:CDC37

Class:IdReaction:9698844
_displayNameMLKL binds HSP90:CDC37
_doReleaseTRUE
_timestamp2020-08-31 16:34:03
authored[InstanceEdit:9689635] Shamovsky, Veronica, 2020-05-21
compartment[Compartment:70101] cytosol
created[InstanceEdit:9698845] Shamovsky, Veronica, 2020-08-30
edited[InstanceEdit:9698858] Shamovsky, Veronica, 2020-08-30
input[Complex:1225828] CDC37 [cytosol] [Homo sapiens]
[Complex:1221657] HSP90 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:5218901] MLKL [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9698850] An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client
[LiteratureReference:9688457] HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death
[LiteratureReference:9688477] Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis
modified[InstanceEdit:9698857] Shamovsky, Veronica, 2020-08-30
[InstanceEdit:9698880] Shamovsky, Veronica, 2020-08-31
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameMLKL binds HSP90:CDC37
MLKL+ HSP90 homodimer + CDC37 homodimer => MLKL:HSP90:CDC37
output[Complex:9698842] MLKL:HSP90:CDC37 [cytosol] [Homo sapiens]
releaseDate2020-09-15
reviewed[InstanceEdit:9698846] Murphy, James M, 2020-08-28
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9698851] R-HSA-9698844.2
summation[Summation:9698848] The pseudokinase mixed lineage kinase domain-like (MLKL), is...
(hasEvent)[Pathway:5675482] Regulation of necroptotic cell death [Homo sapiens]
(updatedInstance)[_UpdateTracker:9953571] Update Tracker - [Reaction:9698844] MLKL binds HSP90:CDC37 - v93:[modifyText]
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