Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person FLT3 ITD- and STAT5-dependent NOX4 gene expression

Class:Id	BlackBoxEvent:9698762
_displayName	FLT3 ITD- and STAT5-dependent NOX4 gene expression
_doRelease	TRUE
_timestamp	2020-11-06 20:53:47
authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
compartment	[Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:9698733] Rothfels, Karen, 2020-08-28
disease	[Disease:9630839] acute myeloid leukemia [Disease:1500689] cancer
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
input	[EntityWithAccessionedSequence:9698757] NOX4 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9697866] Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling [LiteratureReference:9698765] Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/ PTPRJ [LiteratureReference:9698736] Loss of DEP-1 (Ptprj) promotes myeloproliferative disease in FLT3-ITD acute myeloid leukemia [LiteratureReference:9698748] NOX-driven ROS formation in cell transformation of FLT3-ITD-positive AML [LiteratureReference:9698776] NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells
modified	[InstanceEdit:9698791] Rothfels, Karen, 2020-08-28 [InstanceEdit:9706570] Rothfels, Karen, 2020-11-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FLT3 ITD- and STAT5-dependent NOX4 gene expression
output	[EntityWithAccessionedSequence:5212694] NOX4 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9698754] p-STAT5 binds the NOX4 promoter [Homo sapiens] [BlackBoxEvent:9698033] p-STAT5 translocates to nucleus downstream of mutant FLT3 [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9698743] Positive gene expression regulation by 'NOX4 gene:p-STAT5 [nucleoplasm]'
releaseDate	2020-12-08
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9698784] R-HSA-9698762.2
summation	[Summation:9698759] NOX4 expression is upregulated in a FLT3 ITD- and STAT5-depe...
(hasEvent)	[Pathway:9702518] STAT5 activation downstream of FLT3 ITD mutants [Homo sapiens] [Pathway:9703465] Signaling by FLT3 fusion proteins [Homo sapiens]
(precedingEvent)	[Reaction:9698758] FLT3 ITD- and NOX4-dependent H2O2 production [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by FLT3 ITD- and STAT5-dependent NOX4 gene expression (9698762)