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Details on Person Human cytomegalovirus (HCMV) protein pUL36 was found to bind...
| Class:Id | Summation:9698679 |
|---|---|
| _displayName | Human cytomegalovirus (HCMV) protein pUL36 was found to bind... |
| _timestamp | 2020-08-28 13:27:26 |
| created | [InstanceEdit:9698673] Shamovsky, Veronica, 2020-08-28 |
| literatureReference | [LiteratureReference:9698672] Human cytomegalovirus protein pUL36: A dual cell death pathway inhibitor [LiteratureReference:5692545] A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation |
| text | Human cytomegalovirus (HCMV) protein pUL36 was found to bind mixed lineage kinase domain-like protein (MLKL) and target MLKL for degradation in HCMV-infected TERT-immortalized primary human fetal foreskin fibroblasts (HFFF-TERTs) (Fletcher-Etherington A et al. 2020). Furthermore, mutation of pUL36 Cys131 abrogated MLKL degradation and restored necroptosis in HFFF-TERTs. The same residue was also required for pUL36-mediated inhibition of apoptosis by preventing proteolytic activation of procaspase-8, suggesting that pUL36 acts as a multifunctional inhibitor of both apoptotic and necroptotic cell death (Fletcher-Etherington A et al. 2020; Skaletskaya A et al. 2001). |
| (summation) | [Reaction:9698677] HCMV UL36 binds MLKL [Homo sapiens] |
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No pathways have been reviewed or authored by Human cytomegalovirus (HCMV) protein pUL36 was found to bind... (9698679)
