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Details on Person UniProt:P0DTE5 UGT2A2
| Class:Id | ReferenceGeneProduct:9698556 |
|---|---|
| _chainChangeLog | chain:1-536 for 9698556 added on Wed August 26 2020 |
| _displayName | UniProt:P0DTE5 UGT2A2 |
| _timestamp | 2025-08-15 22:16:06 |
| chain | chain:1-536 |
| checksum | 2234435E46224749 |
| comment | FUNCTION UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:19858781, PubMed:23288867, PubMed:23756265). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:19858781, PubMed:23756265). Catalyzes the glucuronidation of endogenous estrogen hormone estradiol (PubMed:18719240, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Shows a potential role in detoxification of toxic waste compounds in the amniotic fluid before birth, and air-born chemical after birth (PubMed:19858781).CATALYTIC ACTIVITY glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)CATALYTIC ACTIVITY 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP + H(+)CATALYTIC ACTIVITY 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + UDP + H(+)CATALYTIC ACTIVITY chenodeoxycholate + UDP-alpha-D-glucuronate = chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDPCATALYTIC ACTIVITY lithocholate + UDP-alpha-D-glucuronate = lithocholoyl-24-O-(beta-D-glucuronate) + UDPCATALYTIC ACTIVITY deoxycholate + UDP-alpha-D-glucuronate = deoxycholoyl-24-O-(beta-D-glucuronate) + UDPCATALYTIC ACTIVITY hyocholate + UDP-alpha-D-glucuronate = hyocholoyl-24-O-(beta-D-glucuronate) + UDPCATALYTIC ACTIVITY hyodeoxycholate + UDP-alpha-D-glucuronate = hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP + H(+)BIOPHYSICOCHEMICAL PROPERTIES Mainly expressed in the nasal mucosa.MISCELLANEOUS UGT2A2 isoform is part of the UGT2A complex locus which displays alternative use of promoters and exons. The locus is defined by 2 alternative promoters resulting in 2 functionally active polypeptides UGT2A1 and UGT2A2. Alternative splicing of exons results in additional isoforms for each protein class.SIMILARITY Belongs to the UDP-glycosyltransferase family. |
| created | [InstanceEdit:9698430] Weiser, JD |
| description | recommendedName: fullName evidence="6"UDP-glucuronosyltransferase 2A2 shortName: UDPGT 2A2 ecNumber evidence="2 3 4 5"2.4.1.17 |
| geneName | UGT2A2 |
| identifier | P0DTE5 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Endoplasmic reticulum Glycoprotein Glycosyltransferase Lipid metabolism Membrane Proteomics identification Reference proteome Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | UGT2A2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990482] ENSEMBL:ENSG00000271271 UGT2A2 [Homo sapiens] |
| secondaryIdentifier | UD2A2_HUMAN B4E2F4 D3GER1 D3GER2 E9PDM7 J3KNA3 Q9Y4X1 |
| sequenceLength | 536 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:9698557] UniProt:P0DTE5-1 UGT2A2 [Homo sapiens] [ReferenceIsoform:9698558] UniProt:P0DTE5-2 UGT2A2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9698802] UGT2A2 [endoplasmic reticulum membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P0DTE5 UGT2A2 (9698556)
