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Details on Person FLT3 mutants recruit PIK3R1 through phosphorylated GAB2

Class:Id	Reaction:9698179
_displayName	FLT3 mutants recruit PIK3R1 through phosphorylated GAB2
_doRelease	TRUE
_timestamp	2020-11-06 20:54:27
authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9698177] Rothfels, Karen, 2020-08-24
disease	[Disease:1500689] cancer
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
entityFunctionalStatus	[EntityFunctionalStatus:9698188] gain_of_function of p-6Y FLT3 mutant dimers:GRB2:p-Y GAB2 [plasma membrane]
inferredFrom	[Reaction:9607226] Active Flt3:Grb2:p-Y-Gab2 binds Pik3r1 [Mus musculus]
input	[EntityWithAccessionedSequence:74789] PIK3R1 [cytosol] [Homo sapiens] [Complex:9697977] p-6Y FLT3 mutant dimers:GRB2:p-Y GAB2 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6786770] Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase [LiteratureReference:9604764] A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival [LiteratureReference:9697911] p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells [LiteratureReference:9697839] FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications
modified	[InstanceEdit:9702071] Rothfels, Karen, 2020-09-28 [InstanceEdit:9702481] Rothfels, Karen, 2020-09-30 [InstanceEdit:9703429] Rothfels, Karen, 2020-10-06 [InstanceEdit:9706570] Rothfels, Karen, 2020-11-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FLT3 mutants recruit PIK3R1 through phosphorylated GAB2
normalReaction	[Reaction:9607224] Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1 [Homo sapiens]
output	[Complex:9698178] p-6Y FLT3 mutant dimers:GRB2:p-Y GAB2:PIK3R1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9698000] FLT3 mutants:GRB2 bind GAB2 [Homo sapiens] [Reaction:9695841] FLT3 mutant dimers bind GRB2 [Homo sapiens]
releaseDate	2020-12-08
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9698183] R-HSA-9698179.2
summation	[Summation:9698176] FLT3 ITD mutants signal through the PI3K/AKT pathway in a GR...
(hasEvent)	[Pathway:9703648] Signaling by FLT3 ITD and TKD mutants [Homo sapiens]
(precedingEvent)	[Reaction:9698174] FLT3 mutants recruit PIK3CA through PIK3R1 [Homo sapiens]
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