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Details on Person FLT3 ITD- and STAT5-dependent CDKN1A gene expression

Class:Id	BlackBoxEvent:9698043
_displayName	FLT3 ITD- and STAT5-dependent CDKN1A gene expression
_doRelease	TRUE
_timestamp	2020-11-06 21:12:51
authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9698044] Rothfels, Karen, 2020-08-21
disease	[Disease:1500689] cancer
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
input	[EntityWithAccessionedSequence:3786256] CDKN1A gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9697845] Flt3 mutation activates p21WAF1/CIP1 gene expression through the action of STAT5
modified	[InstanceEdit:9698733] Rothfels, Karen, 2020-08-28 [InstanceEdit:9706570] Rothfels, Karen, 2020-11-06 [InstanceEdit:9706571] Rothfels, Karen, 2020-11-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FLT3 ITD- and STAT5-dependent CDKN1A gene expression
output	[EntityWithAccessionedSequence:182585] CDKN1A [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9698041] p-STAT5 binds the CDKN1A gene [Homo sapiens] [BlackBoxEvent:9698033] p-STAT5 translocates to nucleus downstream of mutant FLT3 [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9698039] Positive gene expression regulation by 'p-STAT5:CDKN1A gene [nucleoplasm]'
releaseDate	2020-12-08
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9698045] R-HSA-9698043.2
summation	[Summation:9697921] STAT5 binding to its cognate sites at positions -692 and -68...
(hasEvent)	[Pathway:9702518] STAT5 activation downstream of FLT3 ITD mutants [Homo sapiens] [Pathway:9703465] Signaling by FLT3 fusion proteins [Homo sapiens]
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No pathways have been reviewed or authored by FLT3 ITD- and STAT5-dependent CDKN1A gene expression (9698043)