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Details on Person PTPN11:p-STAT5 binds BCL2L1 promoter

Class:Id	Reaction:9698021
_displayName	PTPN11:p-STAT5 binds BCL2L1 promoter
_doRelease	TRUE
_timestamp	2020-11-06 20:55:10
authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9698022] Rothfels, Karen, 2020-08-21
disease	[Disease:1500689] cancer
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
input	[EntityWithAccessionedSequence:8948464] BCL2L1 gene [nucleoplasm] [Homo sapiens] [Complex:9697993] PTPN11:p-STAT5 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9604970] The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo [LiteratureReference:9604777] Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2
modified	[InstanceEdit:9704328] Rothfels, Karen, 2020-10-07 [InstanceEdit:9706570] Rothfels, Karen, 2020-11-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PTPN11:p-STAT5 binds BCL2L1 promoter
output	[Complex:9698019] BCL2L1 gene:PTPN11:p-STAT5 [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9698016] PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3 [Homo sapiens] [Reaction:9698013] PTPN11:p-STAT5 dissociates from mutant FLT3 [Homo sapiens]
releaseDate	2020-12-08
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9698023] R-HSA-9698021.2
summation	[Summation:9697930] PTPN11:STAT5 binds to gamma interferon activation sites (GAS...
(hasEvent)	[Pathway:9702518] STAT5 activation downstream of FLT3 ITD mutants [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9698026] FLT3 ITD- and STAT5-dependent BCL2L1 gene expression [Homo sapiens]
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No pathways have been reviewed or authored by PTPN11:p-STAT5 binds BCL2L1 promoter (9698021)