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Details on Person FLT3 ITD mutants phosphorylate STAT5
Class:Id Reaction:9698005 _displayName FLT3 ITD mutants phosphorylate STAT5 _doRelease TRUE _timestamp 2020-11-06 20:53:36 authored [InstanceEdit:9706566] Rothfels, Karen, 2020-11-06 catalystActivity [CatalystActivity:9697998] protein tyrosine kinase activity of p-6Y FLT3 ITD mutant dimers:GRB2:p-Y GAB2:PTPN11:STAT5 [plasma membrane] compartment [Compartment:876] plasma membrane created [InstanceEdit:9698006] Rothfels, Karen, 2020-08-21 disease [Disease:1500689] cancer edited [InstanceEdit:9706566] Rothfels, Karen, 2020-11-06 entityFunctionalStatus [EntityFunctionalStatus:9698192] gain_of_function of p-6Y FLT3 ITD mutant dimers:GRB2:p-Y GAB2:PTPN11:STAT5 [plasma membrane] input [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:9697982] p-6Y FLT3 ITD mutant dimers:GRB2:p-Y GAB2:PTPN11:STAT5 [plasma membrane] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:9649423] Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways [LiteratureReference:9697896] Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines [LiteratureReference:9649425] Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD [LiteratureReference:9697850] Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells [LiteratureReference:9697800] Activation mechanisms of STAT5 by oncogenic Flt3-ITD [LiteratureReference:9697873] SRC is a signaling mediator in FLT3-ITD- but not in FLT3-TKD-positive AML [LiteratureReference:9697836] FES kinases are required for oncogenic FLT3 signaling [LiteratureReference:9697839] FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications [LiteratureReference:9697902] The role of SRC family kinases in FLT3 signaling [LiteratureReference:9697887] Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations [LiteratureReference:9697845] Flt3 mutation activates p21WAF1/CIP1 gene expression through the action of STAT5 [LiteratureReference:9697855] Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival [LiteratureReference:9697821] CDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia [LiteratureReference:9604970] The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo modified [InstanceEdit:9698204] Rothfels, Karen, 2020-08-24 [InstanceEdit:9702069] Rothfels, Karen, 2020-09-28 [InstanceEdit:9706570] Rothfels, Karen, 2020-11-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name FLT3 ITD mutants phosphorylate STAT5 normalReaction
output [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:9697985] p-6Y FLT3 ITD mutant dimers:GRB2:p-Y GAB2:PTPN11:p-STAT5 [plasma membrane] [Homo sapiens] precedingEvent
releaseDate 2020-12-08 reviewed [InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:9698009] R-HSA-9698005.2 summation [Summation:9697928] STAT5 is phosphorylated downstream of FLT3 ITD mutants (Haya... (hasEvent) [Pathway:9702518] STAT5 activation downstream of FLT3 ITD mutants [Homo sapiens] (precedingEvent) [Reaction:9698013] PTPN11:p-STAT5 dissociates from mutant FLT3 [Homo sapiens] [Reaction:9698029] p-STAT5 dissociates from mutant FLT3 [Homo sapiens]
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