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Details on Person FLT3 mutants:GRB2 bind GAB2

Class:IdReaction:9698000
_displayNameFLT3 mutants:GRB2 bind GAB2
_doReleaseTRUE
_timestamp2020-11-06 20:54:30
authored[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:9697999] Rothfels, Karen, 2020-08-21
disease[Disease:1500689] cancer
edited[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
entityFunctionalStatus[EntityFunctionalStatus:9698184] gain_of_function of p-6Y FLT3 mutant dimers:GRB2 [plasma membrane]
input[EntityWithAccessionedSequence:508239] GAB2 [cytosol] [Homo sapiens]
[Complex:9695798] p-6Y FLT3 mutant dimers:GRB2 [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:6786770] Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase
[LiteratureReference:9604770] Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3
[LiteratureReference:9604764] A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival
[LiteratureReference:9697839] FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications
modified[InstanceEdit:9698204] Rothfels, Karen, 2020-08-24
[InstanceEdit:9702482] Rothfels, Karen, 2020-09-30
[InstanceEdit:9706570] Rothfels, Karen, 2020-11-06
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameFLT3 mutants:GRB2 bind GAB2
normalReaction
output[Complex:9697974] p-6Y FLT3 mutant dimers:GRB2:GAB2 [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2020-12-08
reviewed[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9698001] R-HSA-9698000.2
summation[Summation:9697927] GRB2 recruits the adaptor GAB2 to activated FLT3 receptors (...
(hasEvent)[Pathway:9703648] Signaling by FLT3 ITD and TKD mutants [Homo sapiens]
(precedingEvent)[Reaction:9698003] FLT3 mutants phosphorylate GAB2 [Homo sapiens]
[Reaction:9698179] FLT3 mutants recruit PIK3R1 through phosphorylated GAB2 [Homo sapiens]
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No pathways have been reviewed or authored by FLT3 mutants:GRB2 bind GAB2 (9698000)