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Details on Person Flt3 mutation activates p21WAF1/CIP1 gene expression through the action of STAT5

Class:Id	LiteratureReference:9697845
_displayName	Flt3 mutation activates p21WAF1/CIP1 gene expression through the action of STAT5
_timestamp	2020-08-21 13:59:49
author	[Person:9697841] Takahashi, Shinichiro [Person:9697846] Harigae, Hideo [Person:9697842] Kaku, Mitsuo [Person:9697843] Sasaki, Takeshi [Person:188709] Licht, JD
created	[InstanceEdit:9697844] Rothfels, Karen, 2020-08-21
journal	Biochem. Biophys. Res. Commun.
pages	85-92
pubMedIdentifier	15003515
title	Flt3 mutation activates p21WAF1/CIP1 gene expression through the action of STAT5
volume	316
year	2004
(literatureReference)	[Reaction:9698005] FLT3 ITD mutants phosphorylate STAT5 [Homo sapiens] [Reaction:9698007] FLT3 ITD mutants bind STAT5 through GAB2:PTPN11 [Homo sapiens] [Reaction:9698029] p-STAT5 dissociates from mutant FLT3 [Homo sapiens] [BlackBoxEvent:9698033] p-STAT5 translocates to nucleus downstream of mutant FLT3 [Homo sapiens] [Reaction:9698041] p-STAT5 binds the CDKN1A gene [Homo sapiens] [BlackBoxEvent:9698043] FLT3 ITD- and STAT5-dependent CDKN1A gene expression [Homo sapiens] [Pathway:9702518] STAT5 activation downstream of FLT3 ITD mutants [Homo sapiens] [Complex:9698036] p-STAT5:CDKN1A gene [nucleoplasm] [Homo sapiens]
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