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Details on Person Endocytosis of SARS-CoV-2 Virion

Class:Id	Reaction:9697423
_displayName	Endocytosis of SARS-CoV-2 Virion
_doRelease	TRUE
_timestamp	2022-04-29 20:03:44
authored	[InstanceEdit:9699040] Gillespie, Marc E, 2020-09-09
compartment	[Compartment:528865] endocytic vesicle lumen
created	[InstanceEdit:9697422] Gillespie, Marc E, 2020-08-14
disease	[Disease:9683912] COVID-19
edited	[InstanceEdit:9699008] Gillespie, Marc E, 2020-09-05
inferredFrom	[Reaction:9686711] Endocytosis of SARS-CoV-1 Virion [Homo sapiens]
input	[Complex:9694785] S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9687538] Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry [LiteratureReference:9687552] Mechanisms of coronavirus cell entry mediated by the viral spike protein [LiteratureReference:9687563] S protein of severe acute respiratory syndrome-associated coronavirus mediates entry into hepatoma cell lines and is targeted by neutralizing antibodies in infected patients [LiteratureReference:9687556] pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN
modified	[InstanceEdit:9697426] Gillespie, Marc E, 2020-08-14 [InstanceEdit:9697427] Gillespie, Marc E, 2020-08-14 [InstanceEdit:9697690] D'Eustachio, Peter, 2020-08-19 [InstanceEdit:9698052] D'Eustachio, Peter, 2020-08-21 [InstanceEdit:9698825] D'Eustachio, Peter, 2020-08-28 [InstanceEdit:9698952] D'Eustachio, Peter, 2020-08-31 [InstanceEdit:9699043] Gillespie, Marc E, 2020-09-09 [InstanceEdit:9699088] Matthews, Lisa, 2020-09-10 [InstanceEdit:9735084] Jassal, Bijay, 2021-06-21 [InstanceEdit:9751260] Matthews, Lisa, 2021-08-24 [InstanceEdit:9763978] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9767451] Stephan, Ralf, 2022-02-27 [InstanceEdit:9773094] Gillespie, Marc E, 2022-04-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Endocytosis of SARS-CoV-2 Virion
output	[Complex:9694758] S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2 [endocytic vesicle lumen] [Homo sapiens] [DefinedSet:2076618] HSPGs [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9678128] Spike glycoprotein of SARS coronavirus binds ACE2 on host cell [Homo sapiens] [BlackBoxEvent:9683488] ACE2 is glycosylated to glycosylated-ACE2 [Homo sapiens] [Reaction:9685542] Viral release [Homo sapiens] [Reaction:9694579] Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell [Homo sapiens] [BlackBoxEvent:9698988] Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid [Homo sapiens]
regulationReference	[RegulationReference:9686691] Negative regulation by 'IFITM1 [plasma membrane]' Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9697425] R-HSA-9697423.5
summation	[Summation:9697424] This COVID-19 pathway has been created by a combination of c...
(hasEvent)	[Pathway:9694614] Attachment and Entry [Homo sapiens]
(precedingEvent)	[Reaction:9694287] Cleavage of S protein into S1:S2 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775095] Update Tracker - [Reaction:9697423] Endocytosis of SARS-CoV-2 Virion - v80:[addOutput] [_UpdateTracker:9775446] Update Tracker - [Reaction:9697423] Endocytosis of SARS-CoV-2 Virion - v79:[removeRegulator] [_UpdateTracker:9775621] Update Tracker - [Reaction:9697423] Endocytosis of SARS-CoV-2 Virion - v78:[addRegulator] [_UpdateTracker:9776107] Update Tracker - [Reaction:9697423] Endocytosis of SARS-CoV-2 Virion - v77:[modifyText]
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No pathways have been reviewed or authored by Endocytosis of SARS-CoV-2 Virion (9697423)