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Details on Person Defective RpoB in Mtb RNAP transcribes RNA polyanion

Class:Id	Polymerisation:9697084
_displayName	Defective RpoB in Mtb RNAP transcribes RNA polyanion
_doRelease	TRUE
_timestamp	2024-07-06 08:09:05
authored	[InstanceEdit:9638888] Stephan, Ralf, 2019-03-06
catalystActivity	[CatalystActivity:9638869] DNA-directed RNA polymerase activity of mutant RNAP [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9697083] Jassal, Bijay, 2020-08-05
disease	[Disease:1660556] tuberculosis
edited	[InstanceEdit:9697083] Jassal, Bijay, 2020-08-05
input	[SimpleEntity:9638778] RNA polyanion [cytosol] [SimpleEntity:9638762] RNTP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9638856] Mapping and sequencing of mutations in the Escherichia coli rpoB gene that lead to rifampicin resistance [LiteratureReference:9638870] Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis [LiteratureReference:9638834] Source of the Fitness Defect in Rifamycin-Resistant Mycobacterium tuberculosis RNA Polymerase and the Mechanism of Compensation by Mutations in the β' Subunit
modified	[InstanceEdit:9697090] Jassal, Bijay, 2020-08-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9915435] Stephan, Ralf, 2024-07-06
name	Defective RpoB in Mtb RNAP transcribes RNA polyanion
output	[Polymer:9638756] RNA(n+1) [cytosol] [SimpleEntity:111294] PPi [cytosol]
relatedSpecies	[Species:176806] Mycobacterium tuberculosis
releaseDate	2019-12-10
reviewed	[InstanceEdit:9664478] Deffur, Armin, Wilkinson, RJ, 2019-10-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9697088] R-HSA-9697084.3
summation	[Summation:9638868] Mutations in several regions of bacterial RNA polymerase (RN...
(hasEvent)	[Pathway:9639775] Antimicrobial action and antimicrobial resistance in Mtb [Homo sapiens]
(replacementInstances)	[_Deleted:9697097] Deletion of instance: 9638843
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No pathways have been reviewed or authored by Defective RpoB in Mtb RNAP transcribes RNA polyanion (9697084)