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Details on Person FLT3 R595_L601dup [plasma membrane]

Class:Id	EntityWithAccessionedSequence:9696032
_displayName	FLT3 R595_L601dup [plasma membrane]
_timestamp	2023-04-01 04:43:15
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9696040] Rothfels, Karen, 2020-07-17
crossReference	[DatabaseIdentifier:9832470] COSMIC:COSV54045432
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
endCoordinate	993
hasModifiedResidue	[FragmentInsertionModification:9696029] Insertion of residues 595 to 601 at 602 from UniProt:P36888 FLT3
literatureReference	[LiteratureReference:9649423] Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways [LiteratureReference:9649425] Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD [LiteratureReference:9696007] FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model [LiteratureReference:9604770] Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3
modified	[InstanceEdit:9697942] Rothfels, Karen, 2020-08-21 [InstanceEdit:9831175] Orlic-Milacic, Marija, 2023-03-20 [InstanceEdit:9832471] Orlic-Milacic, Marija, 2023-04-01 [InstanceEdit:9832472] Orlic-Milacic, Marija, 2023-04-01
name	FLT3 R595_L601dup ITD3 N51 W51
referenceEntity	[ReferenceGeneProduct:54914] UniProt:P36888 FLT3 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9696066] R-HSA-9696032.2
startCoordinate	27
(hasComponent)	[Complex:9696074] FLT3 R595_L601dup dimer [plasma membrane] [Homo sapiens]
(hasMember)	[CandidateSet:9691152] juxtamembrane domain mutants of FLT3 [plasma membrane] [Homo sapiens] [DefinedSet:9699540] tandutinib-sensitive FLT3 mutants [plasma membrane] [Homo sapiens]
(replacementInstances)	[_Deleted:9832476] Deletion of instance: 9696048
(updatedInstance)	[_UpdateTracker:9905376] Update Tracker - [EntityWithAccessionedSequence:9696032] FLT3 R595_L601dup [plasma membrane] - v85:[addLiteratureReference, modifyName]
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No pathways have been reviewed or authored by FLT3 R595_L601dup [plasma membrane] (9696032)