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Details on Person The cytosolic enzyme sphingosine kinase 2 (SPHK2) catalyzes ...
| Class:Id | Summation:9695948 |
|---|---|
| _displayName | The cytosolic enzyme sphingosine kinase 2 (SPHK2) catalyzes ... |
| _timestamp | 2023-10-07 10:11:04 |
| created | [InstanceEdit:9695955] Jassal, Bijay, 2020-07-16 |
| literatureReference | [LiteratureReference:9695942] SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism |
| modified | [InstanceEdit:9843384] Stephan, Ralf, 2023-09-08 [InstanceEdit:9845648] Stephan, Ralf, 2023-10-07 |
| text | The cytosolic enzyme sphingosine kinase 2 (SPHK2) catalyzes the phosphorylation of sphingoids (SPG) to sphingoid 1-phosphate (S1P). The main product is sphingosine 1-phosphate, a bioactive lipid that acts extracellularly on G protein-coupled receptors of the S1P1/EDG-1 subfamily (Liu et al., 2000; reviewed by Siow & Wattenberg, 2011). Through alternative splicing, the isoforms of SK2a and SK2b are produced that show functional differences in their activity (reviewed by Hatoum et al., 2017). In contrast to pro-survival SPHK1, the BH3-only protein SPHK2 inhibits cell growth and enhances apoptosis (Maceyka et al., 2005). |
| (summation) | [Reaction:9695949] SPHK2 phosphorylates sphingoid [Homo sapiens] |
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