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Details on Person nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand)

Class:IdReaction:9694721
_displayNamensp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand)
_doReleaseTRUE
_timestamp2022-04-29 20:05:43
authored[InstanceEdit:9697308] Orlic-Milacic, Marija, 2020-08-12
[InstanceEdit:9697675] Senff-Ribeiro, Andrea, 2020-08-12
catalystActivity[CatalystActivity:9713645] methyltransferase cap1 activity of m7GpppA-capped SARS-CoV-2 genomic RNA (plus strand):RTC [double membrane vesicle viral factory outer membrane]
compartment[Compartment:70101] cytosol
[Compartment:9684675] double membrane vesicle viral factory outer membrane
created[InstanceEdit:9694660] Cook, Justin, 2020-07-07
disease[Disease:9683912] COVID-19
edited[InstanceEdit:9697657] Orlic-Milacic, Marija, 2020-08-18
input[SimpleEntity:9639461] S-adenosyl-L-methionine [cytosol]
[Complex:9713643] m7GpppA-capped SARS-CoV-2 genomic RNA (plus strand):RTC [double membrane vesicle viral factory outer membrane] [Severe acute respiratory syndrome coronavirus 2]
isChimericFALSE
literatureReference[LiteratureReference:9696948] Structural basis of RNA cap modification by SARS-CoV-2
[LiteratureReference:9735235] Mn2+ coordinates Cap-0-RNA to align substrates for efficient 2'-O-methyl transfer by SARS-CoV-2 nsp16
[LiteratureReference:9756258] 2'-O methylation of RNA cap in SARS-CoV-2 captured by serial crystallography
[LiteratureReference:9765245] A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2'-O methylation of its first nucleotide
[LiteratureReference:9765247] Substrate Specificity of SARS-CoV-2 Nsp10-Nsp16 Methyltransferase
modified[InstanceEdit:9696974] Orlic-Milacic, Marija, 2020-08-04
[InstanceEdit:9697028] Gillespie, Marc E, 2020-08-04
[InstanceEdit:9697657] Orlic-Milacic, Marija, 2020-08-18
[InstanceEdit:9697658] Orlic-Milacic, Marija, 2020-08-18
[InstanceEdit:9697678] Orlic-Milacic, Marija, 2020-08-19
[InstanceEdit:9698635] Cook, Justin, 2020-08-27
[InstanceEdit:9699043] Gillespie, Marc E, 2020-09-09
[InstanceEdit:9713650] Orlic-Milacic, Marija, 2021-01-27
[InstanceEdit:9735241] Stephan, Ralf, 2021-06-24
[InstanceEdit:9763854] Stephan, Ralf, 2022-02-06
[InstanceEdit:9765248] Stephan, Ralf, 2022-02-15
[InstanceEdit:9773094] Gillespie, Marc E, 2022-04-29
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namensp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand)
output[SimpleEntity:9639443] S-adenosyl-L-homocysteine [cytosol]
[EntityWithAccessionedSequence:9694619] m7G(5')pppAm-capped SARS-CoV-2 genomic RNA (plus strand) [cytosol] [Severe acute respiratory syndrome coronavirus 2]
[Complex:9694302] RTC [double membrane vesicle viral factory outer membrane] [Severe acute respiratory syndrome coronavirus 2]
precedingEvent
relatedSpecies[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate2020-09-15
reviewed[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9695053] R-HSA-9694721.6
summation[Summation:9694267] The function of the non-structural protein nsp16 as a 2'O-me...
(hasEvent)[Pathway:9694686] Replication of the SARS-CoV-2 genome [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9694471] Polyadenylation of SARS-CoV-2 genomic RNA (plus strand) [Homo sapiens]
[NegativePrecedingEvent:9763930] Futile Cycle: nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand)
[NegativePrecedingEvent:9763933] Futile Cycle: nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand)
(updatedInstance)[_UpdateTracker:9775150] Update Tracker - [Reaction:9694721] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand) - v80:[addLiteratureReference, modifyText]
[_UpdateTracker:9775942] Update Tracker - [Reaction:9694721] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand) - v78:[addLiteratureReference]
[_UpdateTracker:9776434] Update Tracker - [Reaction:9694721] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand) - v76:[addOutput, add_removeCatalystActivity, add_removeInput]
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