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Details on Person SARS-CoV-2 plus strand genomic RNA (gRNA), like genomic RNAs...

Class:IdSummation:9694654
_displayNameSARS-CoV-2 plus strand genomic RNA (gRNA), like genomic RNAs...
_timestamp2020-08-12 12:29:00
created[InstanceEdit:9694660] Cook, Justin, 2020-07-07
literatureReference[LiteratureReference:9680317] Host protein interactions with the 3' end of bovine coronavirus RNA and the requirement of the poly(A) tail for coronavirus defective genome replication
[LiteratureReference:9685588] Characterization of the Role of Hexamer AGUAAA and Poly(A) Tail in Coronavirus Polyadenylation
[LiteratureReference:9685589] Identification and Characterization of a Human Coronavirus 229E Nonstructural Protein 8-Associated RNA 3'-Terminal Adenylyltransferase Activity
[LiteratureReference:9697214] The Architecture of SARS-CoV-2 Transcriptome
modified[InstanceEdit:9697272] Orlic-Milacic, Marija, 2020-08-12
[InstanceEdit:9697273] Orlic-Milacic, Marija, 2020-08-12
textSARS-CoV-2 plus strand genomic RNA (gRNA), like genomic RNAs of SARS-CoV-1 and other coronaviruses, is polyadenylated. The poly(A) tail of gRNA is longer than the poly(A) tail of subgenomic SARS-CoV-2 RNAs (Kim et al. 2020). Coronavirus plus strand gRNAs possess a polyadenylation signal in their 3'UTR and are polyadenylated by an undetermined viral RNA polymerase, possibly nsp8 or nsp12 (Spagnolo and Hogue 2000, Peng et al. 2016, Tvarogova et al. 2019).
(summation)[BlackBoxEvent:9694471] Polyadenylation of SARS-CoV-2 genomic RNA (plus strand) [Homo sapiens]
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