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Details on Person Nsp3:nsp4 binds to nsp6

Class:Id	BlackBoxEvent:9694630
_displayName	Nsp3:nsp4 binds to nsp6
_doRelease	TRUE
_timestamp	2022-04-29 20:04:27
authored	[InstanceEdit:9697308] Orlic-Milacic, Marija, 2020-08-12
compartment	[Compartment:9684675] double membrane vesicle viral factory outer membrane
created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
disease	[Disease:9683912] COVID-19
edited	[InstanceEdit:9697657] Orlic-Milacic, Marija, 2020-08-18
inferredFrom	[BlackBoxEvent:9686013] Nsp3:nsp4 binds to nsp6 [Homo sapiens]
input	[Complex:9694366] nsp3:nsp4 [double membrane vesicle viral factory outer membrane] [Severe acute respiratory syndrome coronavirus 2] [DefinedSet:9694770] nsp6 [double membrane vesicle viral factory outer membrane] [Severe acute respiratory syndrome coronavirus 2]
isChimeric	FALSE
modified	[InstanceEdit:9697028] Gillespie, Marc E, 2020-08-04 [InstanceEdit:9697208] Orlic-Milacic, Marija, 2020-08-10 [InstanceEdit:9697657] Orlic-Milacic, Marija, 2020-08-18 [InstanceEdit:9697658] Orlic-Milacic, Marija, 2020-08-18 [InstanceEdit:9697761] Orlic-Milacic, Marija, 2020-08-20 [InstanceEdit:9698635] Cook, Justin, 2020-08-27 [InstanceEdit:9699043] Gillespie, Marc E, 2020-09-09 [InstanceEdit:9773094] Gillespie, Marc E, 2022-04-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Nsp3:nsp4 binds to nsp6
output	[Complex:9694728] nsp3:nsp4:nsp6 [double membrane vesicle viral factory outer membrane] [Severe acute respiratory syndrome coronavirus 2]
precedingEvent	[BlackBoxEvent:9694317] Nsp3, nsp4, and nsp6 produce replicative organelles [Homo sapiens] [BlackBoxEvent:9694389] nsp3 is glycosylated [Homo sapiens] [BlackBoxEvent:9694611] nsp4 is glycosylated [Homo sapiens] [Reaction:9694551] 3CLp cleaves nsp6-11 [Homo sapiens] [Reaction:9694732] 3CLp cleaves pp1ab [Homo sapiens]
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9694978] R-HSA-9694630.3
summation	[Summation:9694437] This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway. The SARS-CoV nsp3 was shown to bind ORF7a and Nsp6 by using proteomics analysis (Neuman et al, 2008)
(hasEvent)	[Pathway:9694271] Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC) [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9694576] nsp3 binds to nsp7-8 and nsp12-16 [Homo sapiens]
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No pathways have been reviewed or authored by Nsp3:nsp4 binds to nsp6 (9694630)