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Details on Person Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell

Class:Id	Reaction:9694579
_displayName	Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell
_doRelease	TRUE
_timestamp	2022-04-29 20:04:54
authored	[InstanceEdit:9699040] Gillespie, Marc E, 2020-09-09
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
disease	[Disease:9683912] COVID-19
edited	[InstanceEdit:9699040] Gillespie, Marc E, 2020-09-09
input	[Complex:9694500] S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] [Severe acute respiratory syndrome coronavirus 2] [EntityWithAccessionedSequence:9683480] glycosylated-ACE2 [plasma membrane] [Homo sapiens] [DefinedSet:2076618] HSPGs [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9683520] Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target [LiteratureReference:9687552] Mechanisms of coronavirus cell entry mediated by the viral spike protein [LiteratureReference:9761396] SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets [LiteratureReference:9761383] Mechanisms of SARS-CoV-2 entry into cells [LiteratureReference:9764465] Glycosylation is a key in SARS-CoV-2 infection [LiteratureReference:9763718] Glycosylation of SARS-CoV-2: structural and functional insights [LiteratureReference:9763712] The glycosylation in SARS-CoV-2 and its receptor ACE2 [LiteratureReference:9766750] SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2 [LiteratureReference:9766721] Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro [LiteratureReference:9766769] Heparan Sulfate Facilitates Spike Protein-Mediated SARS-CoV-2 Host Cell Invasion and Contributes to Increased Infection of SARS-CoV-2 G614 Mutant and in Lung Cancer [LiteratureReference:9766745] Heparan Sulfate Proteoglycans as Attachment Factor for SARS-CoV-2 [LiteratureReference:9766722] Infection and transmission of SARS-CoV-2 depend on heparan sulfate proteoglycans [LiteratureReference:9767459] Characterization of heparin and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein binding interactions
modified	[InstanceEdit:9697028] Gillespie, Marc E, 2020-08-04 [InstanceEdit:9697422] Gillespie, Marc E, 2020-08-14 [InstanceEdit:9698358] Matthews, Lisa, 2020-08-25 [InstanceEdit:9698635] Cook, Justin, 2020-08-27 [InstanceEdit:9698957] Gillespie, Marc E, 2020-09-01 [InstanceEdit:9699043] Gillespie, Marc E, 2020-09-09 [InstanceEdit:9761389] Stephan, Ralf, 2022-01-13 [InstanceEdit:9763983] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9763987] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9764464] Stephan, Ralf, 2022-02-11 [InstanceEdit:9766770] Stephan, Ralf, 2022-02-24 [InstanceEdit:9767449] Stephan, Ralf, 2022-02-27 [InstanceEdit:9767453] Stephan, Ralf, 2022-02-28 [InstanceEdit:9769497] Stephan, Ralf, 2022-03-18 [InstanceEdit:9773094] Gillespie, Marc E, 2022-04-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell
negativePrecedingEvent	[NegativePrecedingEvent:9763982] Futile Cycle: Viral release
output	[Complex:9694785] S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9698988] Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid [Homo sapiens] [Reaction:9694579] Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell [Homo sapiens]
regulatedBy	[NegativeRegulation:9769498] Negative regulation by 'Spike:Spike inhibitors [extracellular region]'
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9694853] R-HSA-9694579.4
summation	[Summation:9694360] SARS-CoV-2 spike protein trimer (S3), as a component of the ...
(hasEvent)	[Pathway:9694614] Attachment and Entry [Homo sapiens]
(precedingEvent)	[Reaction:9694661] TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis [Homo sapiens] [Reaction:9697423] Endocytosis of SARS-CoV-2 Virion [Homo sapiens] [BlackBoxEvent:9698988] Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid [Homo sapiens] [Reaction:9699007] FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9774767] Update Tracker - [Reaction:9694579] Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell - v81:[addRegulator] [_UpdateTracker:9775113] Update Tracker - [Reaction:9694579] Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell - v80:[addInput, add_removeLiteratureReference, modifyText]
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