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Details on Person E and N are recruited to the M lattice

Class:Id	Reaction:9694444
_displayName	E and N are recruited to the M lattice
_doRelease	TRUE
_timestamp	2022-04-29 20:03:36
authored	[InstanceEdit:9696947] Rothfels, Karen, 2020-07-30
compartment	[Compartment:6791047] endoplasmic reticulum-Golgi intermediate compartment membrane
created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
disease	[Disease:9683912] COVID-19
edited	[InstanceEdit:9696947] Rothfels, Karen, 2020-07-30
inferredFrom	[Reaction:9684238] E and N are recruited to the M lattice [Homo sapiens]
input	[Complex:9694371] M lattice [endoplasmic reticulum-Golgi intermediate compartment membrane] [Severe acute respiratory syndrome coronavirus 2] [Complex:9694612] encapsidated SARS-CoV-2 genomic RNA [endoplasmic reticulum-Golgi intermediate compartment membrane] [Severe acute respiratory syndrome coronavirus 2] [Complex:9694408] Ub-3xPalmC-E pentamer [Golgi membrane] [Severe acute respiratory syndrome coronavirus 2] [Complex:9694408] Ub-3xPalmC-E pentamer [Golgi membrane] [Severe acute respiratory syndrome coronavirus 2] [Complex:9694408] Ub-3xPalmC-E pentamer [Golgi membrane] [Severe acute respiratory syndrome coronavirus 2]
isChimeric	FALSE
literatureReference	[LiteratureReference:9680341] The molecular biology of coronaviruses [LiteratureReference:9679510] Human Coronavirus: Host-Pathogen Interaction [LiteratureReference:9685450] Incorporation of spike and membrane glycoproteins into coronavirus virions [LiteratureReference:9684168] Generation of synthetic severe acute respiratory syndrome coronavirus pseudoparticles: implications for assembly and vaccine production [LiteratureReference:9684137] Assembly of human severe acute respiratory syndrome coronavirus-like particles [LiteratureReference:9684142] Assembly of severe acute respiratory syndrome coronavirus RNA packaging signal into virus-like particles is nucleocapsid dependent [LiteratureReference:9684163] Efficient assembly and release of SARS coronavirus-like particles by a heterologous expression system [LiteratureReference:9684187] The M, E, and N structural proteins of the severe acute respiratory syndrome coronavirus are required for efficient assembly, trafficking, and release of virus-like particles [LiteratureReference:9685370] The transmembrane oligomers of coronavirus protein E [LiteratureReference:9682946] Biochemical and functional characterization of the membrane association and membrane permeabilizing activity of the severe acute respiratory syndrome coronavirus envelope protein [LiteratureReference:9682982] Biochemical evidence for the presence of mixed membrane topologies of the severe acute respiratory syndrome coronavirus envelope protein expressed in mammalian cells [LiteratureReference:9685364] Interactions between M protein and other structural proteins of severe, acute respiratory syndrome-associated coronavirus [LiteratureReference:9685362] Expression and membrane integration of SARS-CoV E protein and its interaction with M protein [LiteratureReference:9685354] Coronavirus envelope protein: current knowledge [LiteratureReference:9685353] Coronavirus envelope protein: a small membrane protein with multiple functions [LiteratureReference:9684155] Dissection and identification of regions required to form pseudoparticles by the interaction between the nucleocapsid (N) and membrane (M) proteins of SARS coronavirus [LiteratureReference:9685350] Characterization of protein-protein interactions between the nucleocapsid protein and membrane protein of the SARS coronavirus [LiteratureReference:9685368] Severe acute respiratory syndrome coronavirus membrane protein interacts with nucleocapsid protein mostly through their carboxyl termini by electrostatic attraction
modified	[InstanceEdit:9697028] Gillespie, Marc E, 2020-08-04 [InstanceEdit:9697664] Rothfels, Karen, 2020-08-19 [InstanceEdit:9697760] Rothfels, Karen, 2020-08-20 [InstanceEdit:9698429] Rothfels, Karen, 2020-08-26 [InstanceEdit:9698635] Cook, Justin, 2020-08-27 [InstanceEdit:9698793] Rothfels, Karen, 2020-08-28 [InstanceEdit:9699043] Gillespie, Marc E, 2020-09-09 [InstanceEdit:9763814] Orlic-Milacic, Marija, 2022-02-04 [InstanceEdit:9773094] Gillespie, Marc E, 2022-04-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	E and N are recruited to the M lattice
output	[Complex:9694491] M lattice:E protein:encapsidated SARS-CoV-2 genomic RNA [endoplasmic reticulum-Golgi intermediate compartment membrane] [Severe acute respiratory syndrome coronavirus 2]
precedingEvent	[Reaction:9694487] M protein oligomerization [Homo sapiens] [BlackBoxEvent:9694367] Glycosylated M localizes to the Golgi membrane [Homo sapiens] [BlackBoxEvent:9694555] Protein M localizes to the Golgi membrane [Homo sapiens] [Reaction:9694281] Encapsidation of SARS coronavirus genomic RNA [Homo sapiens] [Reaction:9694455] SUMO-p-N protein dimer binds genomic RNA [Homo sapiens] [BlackBoxEvent:9694568] Nucleoprotein translocates to the ERGIC outer membrane [Homo sapiens] [BlackBoxEvent:9694294] E pentamer is transported to the Golgi [Homo sapiens] [Reaction:9694452] Protein E forms a homopentamer [Homo sapiens]
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9694833] R-HSA-9694444.4
summation	[Summation:9694749] This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway. The ribonucleoprotein complex is recruited to the assembling virion through interactions with the M C-terminal tail, and appears to be independent of viral RNA (Hsieh et al, 2008; Hatakeyama et al, 2008; He et al, 2004; Luo et al, 2006; reviewed in Ujike and Taguchi, 2015). How much of this is fully conserved in SARS-COV-2 remains to be experimentally verified.
(hasEvent)	[Pathway:9694322] Virion Assembly and Release [Homo sapiens]
(precedingEvent)	[Reaction:9694553] Recruitment of Spike trimer to assembling virion [Homo sapiens]
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No pathways have been reviewed or authored by E and N are recruited to the M lattice (9694444)