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Details on Person nsp16:nsp10 [cytosol]
Class:Id Complex:9694416
_displayName nsp16:nsp10 [cytosol]
_timestamp 2021-06-29 00:08:28
compartment [Compartment:70101] cytosol
created [InstanceEdit:9694660] Cook, Justin, 2020-07-07
disease [Disease:9683912] COVID-19
hasComponent
isChimeric FALSE
literatureReference [LiteratureReference:9696799] Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis [LiteratureReference:9696948] Structural basis of RNA cap modification by SARS-CoV-2 [LiteratureReference:9696957] The crystal structure of nsp10-nsp16 heterodimer from SARS-CoV-2 in complex with S-adenosylmethionine [LiteratureReference:9735235] Mn2+ coordinates Cap-0-RNA to align substrates for efficient 2'-O -methyl transfer by SARS-CoV-2 nsp16
modified [InstanceEdit:9696709] Orlic-Milacic, Marija, 2020-07-28 [InstanceEdit:9696956] Orlic-Milacic, Marija, 2020-08-04 [InstanceEdit:9696959] Orlic-Milacic, Marija, 2020-08-04 [InstanceEdit:9735483] Stephan, Ralf, 2021-06-29
name nsp16:nsp10
species [Species:9681683] Severe acute respiratory syndrome coronavirus 2
stableIdentifier [StableIdentifier:9694893] R-COV-9694416.2
summation [Summation:9694775] This COVID-19 Complex instance was generated via electronic inference from a curated CoV-1 (Human SARS coronavirus) Reactome instance. In Reactome, inference is the process used to automatically create orthologous Pathways, Reactions and PhysicalEntities from our expertly curated data (https://reactome.org/documentation/inferred-events).
(hasComponent) [Complex:9694302] RTC [double membrane vesicle viral factory outer membrane] [Severe acute respiratory syndrome coronavirus 2]
(input) [BlackBoxEvent:9694576] nsp3 binds to nsp7-8 and nsp12-16 [Homo sapiens]
(output) [Reaction:9694445] nsp16 binds nsp10 [Homo sapiens]
(updatedInstance) [_UpdateTracker:9902567] Update Tracker - [Complex:9694416] nsp16:nsp10 [cytosol] - v78:[addHasComponent, addLiteratureReference]
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Protein identifiers
No pathways have been reviewed or authored by nsp16:nsp10 [cytosol] (9694416)