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Details on Person pp1a cleaves itself

Class:Id	Reaction:9694377
_displayName	pp1a cleaves itself
_doRelease	TRUE
_timestamp	2022-04-29 20:05:58
authored	[InstanceEdit:9698832] Stephan, Ralf, 2020-08-28
catalystActivity	[CatalystActivity:9694557] cysteine-type endopeptidase activity of pp1a dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
disease	[Disease:9683912] COVID-19
edited	[InstanceEdit:9698832] Stephan, Ralf, 2020-08-28
input	[SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [EntityWithAccessionedSequence:9681986] pp1a [cytosol] [Severe acute respiratory syndrome coronavirus 2]
isChimeric	FALSE
literatureReference	[LiteratureReference:9761278] A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process
modified	[InstanceEdit:9696742] Orlic-Milacic, Marija, 2020-07-28 [InstanceEdit:9697028] Gillespie, Marc E, 2020-08-04 [InstanceEdit:9698635] Cook, Justin, 2020-08-27 [InstanceEdit:9698835] Stephan, Ralf, 2020-08-30 [InstanceEdit:9699043] Gillespie, Marc E, 2020-09-09 [InstanceEdit:9761276] Stephan, Ralf, 2022-01-12 [InstanceEdit:9763814] Orlic-Milacic, Marija, 2022-02-04 [InstanceEdit:9773094] Gillespie, Marc E, 2022-04-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	pp1a cleaves itself
output	[EntityWithAccessionedSequence:9694778] pp1a-nsp1-4 [cytosol] [Severe acute respiratory syndrome coronavirus 2] [EntityWithAccessionedSequence:9681994] pp1a-3CL [cytosol] [Severe acute respiratory syndrome coronavirus 2] [EntityWithAccessionedSequence:9694668] pp1a-nsp6-11 [cytosol] [Severe acute respiratory syndrome coronavirus 2]
precedingEvent	[BlackBoxEvent:9694567] pp1a forms a dimer [Homo sapiens] [BlackBoxEvent:9694334] mRNA1 is translated to pp1a [Homo sapiens] [BlackBoxEvent:9694334] mRNA1 is translated to pp1a [Homo sapiens] [Reaction:9694723] Uncoating of SARS-CoV-2 Genome [Homo sapiens] [BlackBoxEvent:9694471] Polyadenylation of SARS-CoV-2 genomic RNA (plus strand) [Homo sapiens]
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9695033] R-HSA-9694377.4
summation	[Summation:9694691] The crucial step of autocleavage of pp1a involves the format...
(hasEvent)	[Pathway:9694301] Maturation of replicase proteins [Homo sapiens]
(precedingEvent)	[Reaction:9694333] 3CLp forms a homodimer [Homo sapiens] [Reaction:9694338] nsp1-4 cleaves itself [Homo sapiens] [Reaction:9694551] 3CLp cleaves nsp6-11 [Homo sapiens] [Reaction:9694625] nsp3 cleaves nsp1-4 [Homo sapiens] [BlackBoxEvent:9698265] Enhanced autophagosome formation [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775253] Update Tracker - [Reaction:9694377] pp1a cleaves itself - v80:[add_removeLiteratureReference, modifyText]
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No pathways have been reviewed or authored by pp1a cleaves itself (9694377)