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Details on Person Spike protein gets palmitoylated

Class:IdReaction:9694341
_displayNameSpike protein gets palmitoylated
_doReleaseTRUE
_timestamp2022-04-29 20:04:57
authored[InstanceEdit:9696918] Stephan, Ralf, 2020-07-22
catalystActivity[CatalystActivity:9766354] protein-cysteine S-palmitoyltransferase activity of Palmitoyltransferases [Golgi membrane]
compartment[Compartment:190626] endoplasmic reticulum-Golgi intermediate compartment
created[InstanceEdit:9694660] Cook, Justin, 2020-07-07
disease[Disease:9683912] COVID-19
edited[InstanceEdit:9698836] Stephan, Ralf, 2020-08-28
input[EntityWithAccessionedSequence:9766369] high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] [Severe acute respiratory syndrome coronavirus 2]
[SimpleEntity:9766371] palmitoyl-CoA [endoplasmic reticulum-Golgi intermediate compartment]
isChimericFALSE
literatureReference[LiteratureReference:9733305] Spike glycoprotein and host cell determinants of SARS-CoV-2 entry and cytopathic effects
[LiteratureReference:9766357] Palmitoylation of SARS-CoV-2 S protein is essential for viral infectivity
[URL:9766359] https://doi.org/10.1101/2020.12.20.423603
[LiteratureReference:9766378] Palmitoylation of SARS-CoV-2 S protein is critical for S-mediated syncytia formation and virus entry
[LiteratureReference:9766399] S-acylation of SARS-CoV-2 spike protein: Mechanistic dissection, in vitro reconstitution and role in viral infectivity
[LiteratureReference:9766383] S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity
[LiteratureReference:9766385] The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike (S) protein and their effects on S protein's subcellular localization, palmitoylation and pseudovirus entry
modified[InstanceEdit:9696929] Stephan, Ralf, 2020-07-30
[InstanceEdit:9697028] Gillespie, Marc E, 2020-08-04
[InstanceEdit:9698635] Cook, Justin, 2020-08-27
[InstanceEdit:9698837] Stephan, Ralf, 2020-08-30
[InstanceEdit:9699043] Gillespie, Marc E, 2020-09-09
[InstanceEdit:9733313] Stephan, Ralf, 2021-06-03
[InstanceEdit:9766361] Stephan, Ralf, 2022-02-20
[InstanceEdit:9766370] Stephan, Ralf, 2022-02-20
[InstanceEdit:9766379] Stephan, Ralf, 2022-02-20
[InstanceEdit:9766381] Stephan, Ralf, 2022-02-21
[InstanceEdit:9768340] Gillespie, Marc E, 2022-03-06
[InstanceEdit:9773094] Gillespie, Marc E, 2022-04-29
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameSpike protein gets palmitoylated
output[EntityWithAccessionedSequence:9696943] high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] [Severe acute respiratory syndrome coronavirus 2]
[SimpleEntity:9766372] CoA-SH [endoplasmic reticulum-Golgi intermediate compartment]
precedingEvent
relatedSpecies[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate2020-09-15
reviewed[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:9733306] Stephan, Ralf, 2021-06-03
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9694927] R-HSA-9694341.5
summation[Summation:9694759] Palmitoylation of SARS-CoV-2 Spike can occur on multiple dif...
(hasEvent)[Pathway:9694548] Maturation of spike protein [Homo sapiens]
(precedingEvent)[Reaction:9694467] Spike protein forms a homotrimer [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775114] Update Tracker - [Reaction:9694341] Spike protein gets palmitoylated - v80:[addCatalystActivity, addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
[_UpdateTracker:9775494] Update Tracker - [Reaction:9694341] Spike protein gets palmitoylated - v78:[add_removeLiteratureReference, modifyText]
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