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Details on Person Trimmed spike protein binds to calnexin

Class:Id	Reaction:9694337
_displayName	Trimmed spike protein binds to calnexin
_doRelease	TRUE
_timestamp	2022-04-29 20:05:08
authored	[InstanceEdit:9696918] Stephan, Ralf, 2020-07-22
catalystActivity	[CatalystActivity:9682842] protein folding chaperone activity of CANX [endoplasmic reticulum lumen]
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
disease	[Disease:9683912] COVID-19
edited	[InstanceEdit:9698836] Stephan, Ralf, 2020-08-28
inferredFrom	[Reaction:9683772] Trimmed spike protein binds to calnexin [Homo sapiens]
input	[EntityWithAccessionedSequence:9696875] high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] [Severe acute respiratory syndrome coronavirus 2]
isChimeric	FALSE
literatureReference	[LiteratureReference:9682911] Monitoring of S protein maturation in the endoplasmic reticulum by calnexin is important for the infectivity of severe acute respiratory syndrome coronavirus
modified	[InstanceEdit:9696929] Stephan, Ralf, 2020-07-30 [InstanceEdit:9697028] Gillespie, Marc E, 2020-08-04 [InstanceEdit:9698635] Cook, Justin, 2020-08-27 [InstanceEdit:9698837] Stephan, Ralf, 2020-08-30 [InstanceEdit:9699043] Gillespie, Marc E, 2020-09-09 [InstanceEdit:9773094] Gillespie, Marc E, 2022-04-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Trimmed spike protein binds to calnexin
output	[EntityWithAccessionedSequence:9696880] high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] [Severe acute respiratory syndrome coronavirus 2]
precedingEvent	[BlackBoxEvent:9696807] N-glycan mannose trimming of Spike [Homo sapiens] [BlackBoxEvent:9694364] N-glycan glucose trimming of Spike [Homo sapiens]
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9695021] R-HSA-9694337.3
summation	[Summation:9694295] This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway. Calnexin transiently binds the unfolded spike protein and prevents its aggregation and premature degradation, ensuring its correct folding (Fukushi et al, 2012).
(hasEvent)	[Pathway:9694548] Maturation of spike protein [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9694780] Spike translocates to ERGIC [Homo sapiens]
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No pathways have been reviewed or authored by Trimmed spike protein binds to calnexin (9694337)