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Details on Person nsp3-4 is glycosylated

Class:Id	BlackBoxEvent:9694331
_displayName	nsp3-4 is glycosylated
_doRelease	TRUE
_timestamp	2022-04-29 20:05:52
authored	[InstanceEdit:9698832] Stephan, Ralf, 2020-08-28
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
disease	[Disease:9683912] COVID-19
edited	[InstanceEdit:9698832] Stephan, Ralf, 2020-08-28
inferredFrom	[BlackBoxEvent:9684275] nsp3-4 is glycosylated [Homo sapiens]
input	[DefinedSet:9694554] nsp3-4 [cytosol] [Severe acute respiratory syndrome coronavirus 2] [SimpleEntity:1131311] a nucleotide sugar [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9684306] Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity
modified	[InstanceEdit:9697028] Gillespie, Marc E, 2020-08-04 [InstanceEdit:9698635] Cook, Justin, 2020-08-27 [InstanceEdit:9698835] Stephan, Ralf, 2020-08-30 [InstanceEdit:9699043] Gillespie, Marc E, 2020-09-09 [InstanceEdit:9773094] Gillespie, Marc E, 2022-04-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	nsp3-4 is glycosylated
output	[DefinedSet:9694479] N-glycan nsp3-4 [endoplasmic reticulum membrane] [Severe acute respiratory syndrome coronavirus 2] [SimpleEntity:9684302] nucleoside 5'-diphosphate(3-) [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:9694338] nsp1-4 cleaves itself [Homo sapiens] [Reaction:9694441] 3CLp cleaves pp1a [Homo sapiens] [Reaction:9694732] 3CLp cleaves pp1ab [Homo sapiens] [Reaction:9694377] pp1a cleaves itself [Homo sapiens]
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9695008] R-HSA-9694331.3
summation	[Summation:9694583] This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway. To process the nsp3/4 cleavage site, PL-PRO and, presumably, nsp3-4 need to be glycosylated and localized to a membrane (Harcourt et al, 2004)
(hasEvent)	[Pathway:9694301] Maturation of replicase proteins [Homo sapiens]
(precedingEvent)	[Reaction:9694601] nsp3-4 cleaves itself [Homo sapiens]
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No pathways have been reviewed or authored by nsp3-4 is glycosylated (9694331)