Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person RHOV (also known as Chp) is an atypical RHO GTPase that is t...
| Class:Id | Summation:9693871 |
|---|---|
| _displayName | RHOV (also known as Chp) is an atypical RHO GTPase that is t... |
| _timestamp | 2021-04-13 12:46:14 |
| created | [InstanceEdit:9693870] Orlic-Milacic, Marija, 2020-07-07 |
| modified | [InstanceEdit:9693914] Orlic-Milacic, Marija, 2020-07-07 [InstanceEdit:9695527] Orlic-Milacic, Marija, 2020-07-14 [InstanceEdit:9695623] Orlic-Milacic, Marija, 2020-07-15 [InstanceEdit:9695878] Orlic-Milacic, Marija, 2020-07-15 [InstanceEdit:9715170] Orlic-Milacic, Marija, 2021-02-16 [InstanceEdit:9727094] Orlic-Milacic, Marija, 2021-04-13 |
| text | RHOV (also known as Chp) is an atypical RHO GTPase that is thought to be constitutively active due to its high intrinsic guanine nucleotide exchange activity. No guanine nucleotide exchange factors (GEFs) nor GTPase activator proteins (GAPs) that act on RHOV have been identified. RHOV is expressed at very low levels. The expression of RHOV is detected during embryonic development in fish (Tay et al. 2010), frog (Guémar et al. 2007) and chicken (Notarnicola et al. 2008). RHOV is involved in neural crest formation, where its expression is induced downstream of WNT signaling. RHOV is thought to regulate cell adhesion, as its zebrafish orthologue is required for proper localization of E-cadherin and beta-catenin at adherens junctions. RHOV activates JNK and induces apoptosis in rat pheochromocytoma cell line PC12 (Shepelev et al 2011) and in macrophages (Song et al. 2015). RHOV gene overexpression is a molecular marker of human lung adenocarcinoma (Shepelev and Korobko 2013, Shukla et al. 2017, Ma et al. 2020, Zhang et al. 2020), where RHOV is likely to act as an oncogene (Chen et al. 2021). For review, please refer to Faure and Fort 2015, and Hodge and Ridley 2020. |
| (summation) | [Pathway:9013424] RHOV GTPase cycle [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by RHOV (also known as Chp) is an atypical RHO GTPase that is t... (9693871)
