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Details on Person UniProt:Q8IMX7-1 Miro
| Class:Id | ReferenceIsoform:9693777 |
|---|---|
| _chainChangeLog | chain:1-652 for 9693777 added on Wed August 26 2020 |
| _displayName | UniProt:Q8IMX7-1 Miro |
| _timestamp | 2024-02-26 03:56:37 |
| chain | chain:1-652 |
| checksum | 5F2F9623EF6CCB19 |
| comment | FUNCTION Mitochondrial GTPase involved in mitochondrial trafficking (PubMed:16055062, PubMed:16717129, PubMed:22396657). Forms an essential protein complex with Milt that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria (PubMed:16717129). Required for axonal transport to synapses within nerve terminals (PubMed:16055062, PubMed:22396657). Required presynaptically but not postsynaptically at neuromuscular junctions (NMJs) (PubMed:16055062). Also involved in the regulation of mitochondrial dynamics by promoting drp1-mediated mitochondrial fission during high calcium conditions, and negatively regulating fission during normal conditions (PubMed:27716788).SUBUNIT Interacts with kinesin-associated protein milt (PubMed:14605208, PubMed:16717129). Interacts with vimar (PubMed:27716788).INTERACTION Flies die at early pupal stage and exhibit abnormal locomotion (PubMed:16055062). Mitochondria in muscles and neurons are abnormally distributed (PubMed:16055062). Instead of being transported into axons and dendrites, mitochondria accumulate in parallel rows in neuronal somata (PubMed:16055062). Mutant NMJs lack presynaptic mitochondria, but neurotransmitter release and acute Ca(2+) buffering is only impaired during prolonged stimulation (PubMed:16055062). RNAi-mediated knockdown perturbs mitochondrial distribution and dynamics (PubMed:27716788). RNAi-mediated knockdown in the dopaminergic (DA) neurons decreases mitochondrial length and mitochondrial flux, and mitochondria accumulate in the most distal boutons of the DA motor neuron nerve terminals (PubMed:22396657).SIMILARITY Belongs to the mitochondrial Rho GTPase family. |
| created | [InstanceEdit:9693773] Orlic-Milacic, Marija, 2020-07-06 |
| description | recommendedName: Mitochondrial Rho GTPase shortName: Miro shortName: dMiro ecNumber: 3.6.5.- |
| geneName | Miro CG5410 |
| identifier | Q8IMX7 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Calcium GTP-binding Hydrolase Membrane Metal-binding Mitochondrion Mitochondrion outer membrane Nucleotide-binding Reference proteome Repeat Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 |
| name | Miro |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | MIRO_DROME Q8IMX6 Q95TT1 |
| sequenceLength | 652 |
| species | [Species:56210] Drosophila melanogaster |
| variantIdentifier | Q8IMX7-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8IMX7-1 Miro (9693777)
