Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person The following guanine nucleotide exchange factors (GEFs) wer...

Class:IdSummation:9692977
_displayNameThe following guanine nucleotide exchange factors (GEFs) wer...
_timestamp2021-02-24 22:35:57
created[InstanceEdit:9692976] Orlic-Milacic, Marija, 2020-06-27
literatureReference[LiteratureReference:9644217] Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins
[LiteratureReference:9692967] Kalirin Dbl-homology guanine nucleotide exchange factor 1 domain initiates new axon outgrowths via RhoG-mediated mechanisms
[LiteratureReference:9644429] Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins
[LiteratureReference:9692946] P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils
[LiteratureReference:5229003] Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2
[LiteratureReference:9679395] Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism
[LiteratureReference:9692965] Ephexin4 and EphA2 mediate resistance to anoikis through RhoG and phosphatidylinositol 3-kinase
[LiteratureReference:9679397] SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis
[LiteratureReference:8980837] Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5
[LiteratureReference:9692903] RhoG signals in parallel with Rac1 and Cdc42
[LiteratureReference:9692974] The Human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth
[LiteratureReference:9644570] Characterization of the activation of small GTPases by their GEFs on membranes using artificial membrane tethering
[LiteratureReference:9692966] Guanine nucleotide exchange catalyzed by dbl oncogene product
[LiteratureReference:8980763] XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC
[LiteratureReference:9644363] Dock10, a Cdc42 and Rac1 GEF, induces loss of elongation, filopodia, and ruffles in cervical cancer epithelial HeLa cells
[LiteratureReference:8980827] The gene for a new brain specific RhoA exchange factor maps to the highly unstable chromosomal region 1p36.2-1p36.3
[LiteratureReference:9714742] TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of rhoG
modified[InstanceEdit:9693037] Orlic-Milacic, Marija, 2020-06-29
[InstanceEdit:9695873] Orlic-Milacic, Marija, 2020-07-15
[InstanceEdit:9696563] Orlic-Milacic, Marija, 2020-07-22
[InstanceEdit:9714743] Orlic-Milacic, Marija, 2021-02-14
[InstanceEdit:9714744] Orlic-Milacic, Marija, 2021-02-14
[InstanceEdit:9714745] Orlic-Milacic, Marija, 2021-02-14
[InstanceEdit:9716785] Orlic-Milacic, Marija, 2021-02-24
textThe following guanine nucleotide exchange factors (GEFs) were shown to bind RHOG and catalyze GDP to GTP exchange on RHOG, resulting in formation of the active RHOG:GTP complex:
ITSN1 (Jaiswal et al. 2013)
KALRN (May et al. 2002)
MCF2 (Zheng et al. 1995; Movilla and Bustelo 1999)
PREX1 (Damoulakis et al. 2014; Jaiswal et al. 2013)
TRIO (Blangy et al. 2000; Estrach et al. 2002; Peurois et al. 2017; Jaiswal et al. 2013; supported by interaction of TRIO with inactive RHOG mutant reported by Bagci et al. 2020)
VAV1 (Schuebel et al. 1998)
VAV3 (Movilla and Bustelo 1999)

The following GEFs, annotated as RHOG candidate GEFs, were shown to activate RHOG in some, but not all studies:
ARHGEF16 (Hiramoto Yamaki et al. 2010; Harada et al. 2011: RHOG directed GEF activity; Bagci et al. 2020: no binding to inactive RHOG)
ARHGEF26 (Ellerbroek et al. 2004: RHOG directed GEF activity; Bagci et al. 2020: no binding to inactive RHOG)
ARHGEF5 (Wang et al. 2009: weak RHOG directed GEF activity; Bagci et al. 2020: no binding to inactive RHOG)
MCF2L (Wennerberg et al. 2002; Jaiswal et al. 2013: RHOG directed GEF activity; Bagci et al. 2020: no binding to inactive RHOG)
VAV2 (Schuebel et al. 1998; Wennerberg et al. 2002; Jaiswal et al. 2013: RHOG directed GEF activity; Bagci et al. 2020: no binding to inactive RHOG)

The following GEFs were shown to either not act on RHOG or to not bind to inactive RHOG mutant in the high throughput screen by Bagci et al. 2020:
AKAP13 (Bagci et al. 2020)
ARHGEF1 (Bagci et al. 2020)
ARHGEF11 (Jaiswal et al. 2013; Bagci et al. 2020)
ARHGEF12 (Jaiswal et al. 2013; Bagci et al. 2020)
ARHGEF17 (Bagci et al. 2020)
ARHGEF2 (Bagci et al. 2020)
ARHGEF28 (Jaiswal et al. 2013)
ARHGEF3 (Arthur et al. 2002)
ARHGEF4 (Jaiswal et al. 2013)
ARHGEF40 (Bagci et al. 2020)
ARHGEF7 (Bagci et al. 2020)
ARHGEF9 (Jaiswal et al. 2013)
BCR (Bagci et al. 2020)
DNMBP (Jaiswal et al. 2013; Bagci et al. 2020)
DOCK6 (Bagci et al. 2020)
DOCK7 (Bagci et al. 2020)
DOCK8 (Bagci et al. 2020)
DOCK9 (Ruiz Lafuente et al. 2015; Bagci et al. 2020)
DOCK10 (Ruiz Lafuente et al. 2015)
DOCK11 (Ruiz Lafuente et al. 2015; Bagci et al. 2020)
ECT2 (Bagci et al. 2020)
FARP1 (Bagci et al. 2020)
NGEF (Bagci et al. 2020)
PLEKHG2 (Bagci et al. 2020)
PLEKHG3 (Bagci et al. 2020)
PLEKHG4 (Bagci et al. 2020)
PLEKHG5 (De Toledo et al. 2001)
SWAP70 (Bagci et al. 2020)
TIAM1 (Jaiswal et al. 2013; Bagci et al. 2020)
(summation)[Reaction:9014433] RHOG GEFs activate RHOG [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by The following guanine nucleotide exchange factors (GEFs) wer... (9692977)
Follow Reactome