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Details on Person nsp7 binds nsp8

Class:Id	Reaction:9691335
_displayName	nsp7 binds nsp8
_doRelease	TRUE
_timestamp	2022-04-29 20:05:54
authored	[InstanceEdit:9697308] Orlic-Milacic, Marija, 2020-08-12 [InstanceEdit:9697675] Senff-Ribeiro, Andrea, 2020-08-12
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9691347] Orlic-Milacic, Marija, 2020-06-11
disease	[Disease:9683912] COVID-19
edited	[InstanceEdit:9697657] Orlic-Milacic, Marija, 2020-08-18
input	[DefinedSet:9691351] nsp8 [cytosol] [Severe acute respiratory syndrome coronavirus 2] [DefinedSet:9765944] N6GMPLys-nsp7 [cytosol] [Severe acute respiratory syndrome coronavirus 2]
isChimeric	FALSE
literatureReference	[LiteratureReference:9691337] Structure of the RNA-dependent RNA polymerase from COVID-19 virus [LiteratureReference:9696799] Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis [LiteratureReference:9697296] Structural analysis of the putative SARS-CoV-2 primase complex [LiteratureReference:9713180] Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2 [LiteratureReference:9697109] Structure of replicating SARS-CoV-2 polymerase [LiteratureReference:9762509] Compartmentalization-aided interaction screening reveals extensive high-order complexes within the SARS-CoV-2 proteome [LiteratureReference:9762524] Revealing the Structural Plasticity of SARS-CoV-2 nsp7 and nsp8 Using Structural Proteomics
modified	[InstanceEdit:9691360] Orlic-Milacic, Marija, 2020-06-11 [InstanceEdit:9695146] Wu, G, 2020-07-11 [InstanceEdit:9696711] Orlic-Milacic, Marija, 2020-07-28 [InstanceEdit:9696801] Orlic-Milacic, Marija, 2020-07-29 [InstanceEdit:9697028] Gillespie, Marc E, 2020-08-04 [InstanceEdit:9697297] Orlic-Milacic, Marija, 2020-08-12 [InstanceEdit:9697647] Orlic-Milacic, Marija, 2020-08-18 [InstanceEdit:9697657] Orlic-Milacic, Marija, 2020-08-18 [InstanceEdit:9697658] Orlic-Milacic, Marija, 2020-08-18 [InstanceEdit:9697678] Orlic-Milacic, Marija, 2020-08-19 [InstanceEdit:9699043] Gillespie, Marc E, 2020-09-09 [InstanceEdit:9713198] Stephan, Ralf, 2021-01-22 [InstanceEdit:9762508] Stephan, Ralf, 2022-01-26 [InstanceEdit:9768603] Stephan, Ralf, 2022-03-14 [InstanceEdit:9768604] Stephan, Ralf, 2022-03-14 [InstanceEdit:9772191] Stephan, Ralf, 2022-04-21 [InstanceEdit:9773094] Gillespie, Marc E, 2022-04-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	nsp7 binds nsp8
output	[Complex:9691348] nsp7:nsp8 [cytosol] [Severe acute respiratory syndrome coronavirus 2]
precedingEvent	[Reaction:9694551] 3CLp cleaves nsp6-11 [Homo sapiens] [Reaction:9694333] 3CLp forms a homodimer [Homo sapiens] [Reaction:9694441] 3CLp cleaves pp1a [Homo sapiens] [Reaction:9694377] pp1a cleaves itself [Homo sapiens] [Reaction:9694732] 3CLp cleaves pp1ab [Homo sapiens] [Reaction:9694333] 3CLp forms a homodimer [Homo sapiens] [BlackBoxEvent:9694274] mRNA1 is translated to pp1ab [Homo sapiens] [Reaction:9765952] nsp12 guanylates nsp7 [Homo sapiens] [Reaction:9694551] 3CLp cleaves nsp6-11 [Homo sapiens] [Reaction:9694441] 3CLp cleaves pp1a [Homo sapiens] [Reaction:9694732] 3CLp cleaves pp1ab [Homo sapiens]
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9691353] R-HSA-9691335.5
summation	[Summation:9691359] SARS-CoV-2 nonstructural proteins nsp7 and nsp8 form a heter...
(hasEvent)	[Pathway:9694271] Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC) [Homo sapiens]
(precedingEvent)	[Reaction:9691363] nsp12 binds nsp7 and nsp8 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9774779] Update Tracker - [Reaction:9691335] nsp7 binds nsp8 - v81:[addLiteratureReference, add_removeInput, modifyText] [_UpdateTracker:9775054] Update Tracker - [Reaction:9691335] nsp7 binds nsp8 - v80:[addLiteratureReference, modifyText] [_UpdateTracker:9776389] Update Tracker - [Reaction:9691335] nsp7 binds nsp8 - v76:[addLiteratureReference]
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No pathways have been reviewed or authored by nsp7 binds nsp8 (9691335)