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Details on Person S1PR1 bind S1P

Class:Id	Reaction:9690449
_displayName	S1PR1 bind S1P
_doRelease	TRUE
_timestamp	2024-03-07 02:51:50
authored	[InstanceEdit:419301] Jassal, Bijay, 2009-04-30
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9690448] Jassal, Bijay, 2020-06-01
input	[SimpleEntity:419305] C18-S1P [extracellular region] [EntityWithAccessionedSequence:419340] S1PR1 [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:419337] An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors [LiteratureReference:419319] The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway [LiteratureReference:419329] Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5 [LiteratureReference:419380] Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins [LiteratureReference:419377] Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9 [LiteratureReference:419350] Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6 [LiteratureReference:419315] Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia [LiteratureReference:419361] Characterization of a novel sphingosine 1-phosphate receptor, Edg-8
modified	[InstanceEdit:9695899] Jassal, Bijay, 2020-07-16 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9864378] Orlic-Milacic, Marija, 2024-03-07
name	S1PR1 bind S1P
output	[Complex:9690450] S1PR1:S1P [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9695890] SPNS2,MFSD2B transport S1P from cytosol to extracellular region [Homo sapiens] [Reaction:428273] SPHK1 phosphorylates sphingoid [Homo sapiens] [Reaction:9695949] SPHK2 phosphorylates sphingoid [Homo sapiens] [Reaction:9678854] S1PR1 binds S1PR1 agonists [Homo sapiens]
regulatedBy	[PositiveRegulation:9690451] Positive regulation by 'S1PR1:S1PR1 agonists [plasma membrane]'
releaseDate	2009-06-24
reviewed	[InstanceEdit:422381] D'Eustachio, P, 2009-05-29 07:44:22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9690453] R-HSA-9690449.3
summation	[Summation:9690452] The human gene EDG1 encodes S1PR1 which binds sphingosine 1-...
(hasEvent)	[Pathway:419408] Lysosphingolipid and LPA receptors [Homo sapiens]
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No pathways have been reviewed or authored by S1PR1 bind S1P (9690449)