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Details on Person Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

Class:IdLiteratureReference:9689630
_displayNameGasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation
_timestamp2020-05-21 01:18:13
author[Person:9686106] Rogers, Corey
[Person:9689627] Erkes, Dan A
[Person:9689628] Nardone, Alexandria
[Person:9689631] Aplin, Andrew E
[Person:141890] Fernandes-Alnemri, T
[Person:141891] Alnemri, ES
created[InstanceEdit:9689629] Shamovsky, Veronica, 2020-05-21
journalNat Commun
pages1689
pubMedIdentifier30976076
titleGasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation
volume10
year2019
(literatureReference)[Reaction:9710254] GSDME oligomerizes [Homo sapiens]
[Reaction:9710353] GSDMD (1-275) binds cardiolipin [Homo sapiens]
[Reaction:9710354] GSDME (1-270) binds cardiolipin [Homo sapiens]
[Summation:9647646] Gasdermin E (GSDME, also known as DFNA5) was identified as a...
[Summation:9647668] Pyroptosis is a form of lytic inflammatory programmed cell d...
[Summation:9647673] The N-terminal domain of gasdermin D (GSDMD(1-275), also kno...
[Summation:9710258] The N‑terminal fragment of gasdermin E (GSDME(1-270)) produc...
[Summation:9710361] Gasdermin D (GSDMD) is cleaved by inflammatory caspases (CAS...
[Summation:9710363] Gasdermin E (GSDME) is cleaved by caspase 3 (CASP3) at D270 ...
[RegulationReference:9710341] Positive regulation by 'GSDME:cardiolipin [mitochondrial outer membrane]' Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation
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