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Details on Person PDZ proteins are highly conserved through evolution; the pri...
| Class:Id | Summation:9689613 |
|---|---|
| _displayName | PDZ proteins are highly conserved through evolution; the pri... |
| _timestamp | 2020-05-21 01:02:04 |
| created | [InstanceEdit:9689615] Shamovsky, Veronica, 2020-05-21 |
| text | PDZ proteins are highly conserved through evolution; the principal function of this large family of proteins is to assemble protein complexes that are involved in many cellular processes, such as cell-cell junctions, cell polarity, recycling, or trafficking. Many PDZ proteins have been identified as targets of viral pathogens by promoting viral replication and spread (Latorre IJ et al. 2005; Storrs CH & Silverstein SJ 2007; Teoh KT et al. 2010; . The association of some viral proteins contating PDZ domain-binding motifs (PBM) with PDZ proteins results in the loss of function, either through proteasome-mediated degradation or aberrant sequestration in cellular structures. In other cases, however, the association of viral PBMs with their PDZ protein targets results in an apparent gain of function of the cellular protein. In both cases, the targeting of PDZ proteins and modulation of the cellular processes that these PDZ proteins regulate are likely to enhance viral replication, dissemination in the host, or transmission to new hosts (Javier RT & Rice AP 2011; Mateo M et al. 2015; . |
| (summation) | [Pathway:9689611] Microbial targeting of PDZ proteins in cell-cell junction [Homo sapiens] |
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No pathways have been reviewed or authored by PDZ proteins are highly conserved through evolution; the pri... (9689613)
