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Details on Person UniProt:A8MZ59-1 LEUTX
| Class:Id | ReferenceIsoform:9688984 |
|---|---|
| _chainChangeLog | chain:1-198 for 9688984 added on Fri May 15 2020 |
| _displayName | UniProt:A8MZ59-1 LEUTX |
| _timestamp | 2023-11-03 15:09:07 |
| chain | chain:1-198 |
| checksum | F9D921B42E6ED11F |
| comment | FUNCTION Paired-like homeobox transcription factor involved in embryogenesis (PubMed:27578796, PubMed:30479355). May act as a regulator of embryo genome activation (PubMed:27578796). Binds to a 36 bp DNA elements containing a 5'-TAATCC-3' sequence motif, referred to as EEA motif (EGA-enriched Alu-motif), present in the promoters of target genes activated in early embryos (PubMed:27578796, PubMed:30479355).FUNCTION Inactive transcriptional activity.INTERACTION During early embryo development, its expression is restricted to the 4-cell to 8-cell stage of the preimplantation embryo.DOMAIN The homeobox contain essential residues (Ile-54, Lys-57, Ala-61) for binding to the 5'-TAATCC-3' motif of the targe gene promoters.DOMAIN The homeobox is incomplete and cannot bind to the 36 bp motif found in the promoters of the target genes.DOMAIN The 9aaTAD motif is a conserved putative nine amino acid transactivation motifs in C-terminus of the LEUTX region.SIMILARITY Belongs to the paired homeobox family. |
| created | [InstanceEdit:9688885] Weiser, JD |
| description | recommendedName: Paired-like homeodomain transcription factor LEUTX alternativeName: Leucine-twenty homeobox alternativeName: fullName evidence="5"Paired-like homeobox transcription factor LEUTX shortName evidence="5"PRD-LIKE homeobox transcription factor LEUTX |
| geneName | LEUTX |
| identifier | A8MZ59 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative initiation DNA-binding Homeobox Nucleus Reference proteome |
| modified | [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | LEUTX |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001251] ENSEMBL:ENSG00000213921 LEUTX [Homo sapiens] |
| secondaryIdentifier | LEUTX_HUMAN A0A1W2PQ33 |
| sequenceLength | 198 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | A8MZ59-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:A8MZ59-1 LEUTX (9688984)
