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Details on Person MLKL binds IP4, IP5 and IP6

Class:Id	Reaction:9687638
_displayName	MLKL binds IP4, IP5 and IP6
_doRelease	TRUE
_timestamp	2020-09-10 14:48:53
authored	[InstanceEdit:9689635] Shamovsky, Veronica, 2020-05-21
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9687619] Shamovsky, Veronica, 2020-05-12
edited	[InstanceEdit:9698642] Shamovsky, Veronica, 2020-08-28
goBiologicalProcess	[GO_BiologicalProcess:422731] regulation of necroptotic process
input	[SimpleEntity:994141] I(1,3,4,5,6)P5 [cytosol] [SimpleEntity:994146] I(1,3,4,6)P4 [cytosol] [SimpleEntity:1629770] IP6 [cytosol] [Complex:5218902] (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9687641] MLKL Requires the Inositol Phosphate Code to Execute Necroptosis [LiteratureReference:9687632] Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites
modified	[InstanceEdit:9687979] Shamovsky, Veronica, 2020-05-13 [InstanceEdit:9696115] Shamovsky, Veronica, 2020-07-17 [InstanceEdit:9697382] Shamovsky, Veronica, 2020-08-14 [InstanceEdit:9697734] Shamovsky, Veronica, 2020-08-20 [InstanceEdit:9698853] Shamovsky, Veronica, 2020-08-30 [InstanceEdit:9699077] Shamovsky, Veronica, 2020-09-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MLKL binds IP4, IP5 and IP6
output	[Complex:9687620] p-S-RIPK1:p-S199,227-RIPK3 oligomer:4xMLKL:IP6,IP5, IP4 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:1855179] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol [Homo sapiens] [Reaction:1855161] I(1,3,4,5,6)P5 transports from the nucleus to the cytosol [Homo sapiens] [Reaction:1855162] I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol [Homo sapiens] [Reaction:1855166] PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol [Homo sapiens] [Reaction:1855155] I(1,3,4,5,6)P5 transports from the ER lumen to the cytosol [Homo sapiens] [Reaction:1855162] I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol [Homo sapiens] [Reaction:1855219] I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol [Homo sapiens]
releaseDate	2020-09-15
reviewed	[InstanceEdit:9692900] D'Eustachio, Peter, 2020-06-26 [InstanceEdit:9698846] Murphy, James M, 2020-08-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9687647] R-HSA-9687638.2
summation	[Summation:9687637] Metabolites of the inositol phosphate (IP) pathway I(1,3,4,6...
(hasEvent)	[Pathway:5675482] Regulation of necroptotic cell death [Homo sapiens]
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No pathways have been reviewed or authored by MLKL binds IP4, IP5 and IP6 (9687638)