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Details on Person Enhanced autophagosome formation

Class:Id	BlackBoxEvent:9687435
_displayName	Enhanced autophagosome formation
_doRelease	TRUE
_timestamp	2022-04-29 20:03:46
authored	[InstanceEdit:9689381] Varusai, Thawfeek, 2020-05-19
compartment	[Compartment:5683628] autophagosome membrane [Compartment:5679192] phagophore assembly site membrane
created	[InstanceEdit:9687436] Varusai, Thawfeek, 2020-05-07
disease	[Disease:9678120] severe acute respiratory syndrome
edited	[InstanceEdit:9689381] Varusai, Thawfeek, 2020-05-19
input	[EntityWithAccessionedSequence:5205651] MAP1LC3B [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9687098] Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins [LiteratureReference:9685176] SARS-coronavirus open reading frame-9b suppresses innate immunity by targeting mitochondria and the MAVS/TRAF3/TRAF6 signalosome [LiteratureReference:9685249] SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes [LiteratureReference:9687112] Coronavirus nsp6 proteins generate autophagosomes from the endoplasmic reticulum via an omegasome intermediate
modified	[InstanceEdit:9687439] Varusai, Thawfeek, 2020-05-07 [InstanceEdit:9687446] D'Eustachio, Peter, 2020-05-08 [InstanceEdit:9689807] D'Eustachio, Peter, 2020-05-21 [InstanceEdit:9690128] Matthews, Lisa, 2020-05-26 [InstanceEdit:9690129] Matthews, Lisa, 2020-05-26 [InstanceEdit:9690130] Varusai, Thawfeek, 2020-05-26 [InstanceEdit:9690209] Gillespie, Marc E, 2020-05-27 [InstanceEdit:9697028] Gillespie, Marc E, 2020-08-04 [InstanceEdit:9698640] Wu, G, 2020-08-28 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9773094] Gillespie, Marc E, 2022-04-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Enhanced autophagosome formation
output	[EntityWithAccessionedSequence:5683641] MAP1LC3B [autophagosome membrane] [Homo sapiens]
precedingEvent	[Reaction:5205663] LC3 binds the autophagosome membrane Atg5-Atg12 complex [Homo sapiens] [Reaction:5205649] p62 links damaged mitochondria to LC3 [Homo sapiens] [Reaction:8959571] LC3 binds the autophagosome membrane Atg5-Atg12 complex [Homo sapiens] [Reaction:8959573] Phosphorylated FUNDC1 links damaged mitochondria to LC3 [Homo sapiens] [Reaction:5678490] ATG16L1 complex transfers LC3 from ATG3 to PE [Homo sapiens] [Reaction:5683593] ATG7:ATG3:LC3 dissociates [Homo sapiens] [Reaction:5679255] WIPI2 binds ATG12:ATG5:ATG16L [Homo sapiens] [BlackBoxEvent:9687121] nsp8 binds MAP1LC3B [Homo sapiens] [BlackBoxEvent:9687109] 8b binds MAP1LC3B [Homo sapiens]
regulatedBy	[PositiveRegulation:5683643] Positive regulation by 'UVRAG complex [cytosol]' [PositiveRegulation:5683644] Positive regulation by 'ESCRT-III [cytosol]' [PositiveRegulation:9687114] Positive regulation by '8b [cytosol]' [PositiveRegulation:9687118] Positive regulation by '9b [cytosol]' [PositiveRegulation:9687091] Positive regulation by 'pp1a-nsp6-11 [cytosol]'
regulationReference	[RegulationReference:9642783] Positive regulation by 'UVRAG complex [cytosol]' Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2020-06-10
reviewed	[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020-05-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9687438] R-HSA-9687435.5
summation	[Summation:9687437] The replicase polyprotein 1a of the human severe acute respi... [Summation:9687116] The replicase polyprotein 1a of the human severe acute respi... [Summation:9687101] It is known that non-structural proteins (nsp) in SARS-CoV v... [Summation:9687107] It is known that non-structural proteins (nsp) in SARS-CoV v...
(hasEvent)	[Pathway:9679504] Translation of Replicase and Assembly of the Replication Transcription Complex [Homo sapiens] [Pathway:9687094] SARS-CoV [Homo sapiens]
(inferredFrom)	[BlackBoxEvent:9698265] Enhanced autophagosome formation [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775688] Update Tracker - [BlackBoxEvent:9687435] Enhanced autophagosome formation - v78:[addSummation]
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No pathways have been reviewed or authored by Enhanced autophagosome formation (9687435)