Query author contributions in Reactome
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Details on Person It is known that non-structural proteins (nsp) in SARS-CoV v...
| Class:Id | Summation:9687101 |
|---|---|
| _displayName | It is known that non-structural proteins (nsp) in SARS-CoV v... |
| _timestamp | 2020-05-06 15:18:32 |
| created | [InstanceEdit:9687103] Varusai, Thawfeek, 2020-05-06 |
| literatureReference | [LiteratureReference:9685249] SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes |
| text | It is known that non-structural proteins (nsp) in SARS-CoV viruses induce the formation of ER-bound double membrane vesicles (DMV) in host cells post infection. These DMVs are decorated with Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) proteins that are involved in autophagosome formation. However, there is no evidence that DMVs are recruited to the autophagy machinery. Studies show that sars8b (8b) can trigger cellular stress, which results in a calcineurin dependent Transcription Factor EB (TFEB) activation and its target genes. This leads to an increase in autophagic flux (Shi C S. et al 2019). |
| (summation) | [BlackBoxEvent:9687435] Enhanced autophagosome formation [Homo sapiens] |
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No pathways have been reviewed or authored by It is known that non-structural proteins (nsp) in SARS-CoV v... (9687101)
