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Details on Person RB1 recruits APC/C:Cdh1 complex to SKP2

Class:Id	Reaction:9686980
_displayName	RB1 recruits APC/C:Cdh1 complex to SKP2
_doRelease	TRUE
_timestamp	2022-02-08 22:40:36
authored	[InstanceEdit:9687445] Orlic-Milacic, Marija, 2020-05-07
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9686975] Orlic-Milacic, Marija, 2020-05-05
edited	[InstanceEdit:9689364] Orlic-Milacic, Marija, 2020-05-18
input	[EntityWithAccessionedSequence:975554] SKP2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:68642] RB1 [nucleoplasm] [Homo sapiens] [Complex:174250] Cdh1:phospho-APC/C complex [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9686974] An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant [LiteratureReference:9686977] Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit
modified	[InstanceEdit:9687149] Orlic-Milacic, Marija, 2020-05-06 [InstanceEdit:9687398] Orlic-Milacic, Marija, 2020-05-07 [InstanceEdit:9687401] Orlic-Milacic, Marija, 2020-05-07 [InstanceEdit:9689368] Orlic-Milacic, Marija, 2020-05-18 [InstanceEdit:9764122] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RB1 recruits APC/C:Cdh1 complex to SKP2
negativePrecedingEvent	[NegativePrecedingEvent:9764120] Futile Cycle: APC/C:Cdh1-mediated degradation of Skp2
output	[Complex:9686978] RB1:SKP2:APC/C:Cdh1 [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9659820] RB1 translocates to the nucleus [Homo sapiens]
releaseDate	2020-06-10
reviewed	[InstanceEdit:9689366] Dick, Frederick Andrew, 2020-05-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9686981] R-HSA-9686980.3
summation	[Summation:9686970] The pocket domain of the RB1 tumor suppressor protein binds ...
(hasEvent)	[Pathway:174178] APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 [Homo sapiens]
(normalReaction)	[FailedReaction:9687377] Defective RB1 does not form a complex with SKP2 and FZR1 [Homo sapiens]
(precedingEvent)	[Reaction:9686969] APC/C:Cdh1 polyubiquitinates SKP2 [Homo sapiens]
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No pathways have been reviewed or authored by RB1 recruits APC/C:Cdh1 complex to SKP2 (9686980)