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Details on Person The pocket domain of the RB1 tumor suppressor protein binds ...
| Class:Id | Summation:9686970 |
|---|---|
| _displayName | The pocket domain of the RB1 tumor suppressor protein binds ... |
| _timestamp | 2020-05-06 12:05:17 |
| created | [InstanceEdit:9686975] Orlic-Milacic, Marija, 2020-05-05 |
| modified | [InstanceEdit:9686987] Orlic-Milacic, Marija, 2020-05-06 |
| text | The pocket domain of the RB1 tumor suppressor protein binds to the N-terminal domain of SKP2, a component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex, whose targets include the cyclin-dependent kinase (CDK) inhibitor p27Kip1 (CDKN1B) (Ji et al. 2004, Binne et al. 2007). RB1 is able to simultanously interact with SKP2 and with FZR1 (Cdh1). FZR1 is a substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C). The interaction with FZR1 involves a different subregion of the pocket domain than the interaction with SKP2, and is partially dependent on the LxCxE binding cleft (Binne et al. 2007). |
| (summation) | [Reaction:9686980] RB1 recruits APC/C:Cdh1 complex to SKP2 [Homo sapiens] |
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